College Football Week 10 Opening Lines, Odds & Best Bets: Notre Dame revenge game loading

The chaos that is college football is in full swing after another top-two team lost over the weekend. Now into Week 10, the College Football Playoff picture is cloudier than it’s ever been, but there are plenty of matchups this week to help clear things up – and when I say plenty, I mean plenty. Not only will we get the long-awaited Miami vs. Notre Dame rematch, but college football fans will also be treated to BYU vs. Utah, Texas vs. Missouri, LSU vs. Alabama, Kentucky vs. Tennessee and Georgia vs. Ole Miss. A Big Ten clash between Oregon and Ohio State also packs a punch as far as program pedigree goes, but this matchup will look much different than what we thought it would look like before the year began. 

Ahead of the first official College Football Playoff rankings, which will be revealed Tuesday night at 7:00 pm ET on ESPN, it’s time to look at the early lines and odds for Week 10 before we cap it off with our usual best bet from the bunch. After a rocking-chair winner on Duke last week, I’m looking for my fifth straight early-week best bet winner. Don’t forget to check Pickswise throughout the week for our CFB predictions on every FBS matchup through the postseason. 

College Football Week 10 Early Lines and Odds

Odds available at bet365 at the time of publishing.

Tuesday, November 3

• Ohio -12.5 (-110) @ Akron; Total 50.5 (Over -114)
• Miami (OH) -6.5 (-114) vs Buffalo; Total 44.5 (Under -114)

Wednesday, November 4

• UMass -3.5 (-105) vs Ball State; Total 49.5 (Under -111)
• Toledo -26.5 (-108) @ Sacramento State; Total 52.5 (-110)
• Eastern Michigan -1.5 (-113) vs Central Michigan; Total 44.5 (Over -114)

Thursday, November 5

• UTSA -6.5 (-121) @ FAU; Total 72.5 (-110)
• James Madison -14.5 (-113) @ Southern Miss; Total 57.5 (Under -113)

Friday, November 6

• SMU -6.5 (-104) vs SMU; Total 55.5 (-110)
• East Carolina -1.5 (-109); Total 40.5 (-110)
• Nebraska -4.5 (-110) @ Illinois; Total 49.5 (-110)
• New Mexico -10.5 (-110) @ Nevada; Total 38.5 (-110)
• Arizona -9.5 (-110) vs TCU; Total 43.5 (Over -111)

Saturday, November 7

• Utah -5.5 (-113) vs BYU; Total 47.5 (Under -111)
• Houston -10.5 (-111) vs Cincinnati; Total 62.5 (-110)
• Clemson -1.5 (-109) @ Syracuse; Total 50.5 (Under -113)
• Florida State -6.5 (-113) @ Boston College; Total 51.5 (-110)
• Northwestern -1.5 (-112) vs Iowa; Total 44.5 (Under -111)
• Baylor -9.5 (-107) vs Iowa State; Total 50.5 (Over -112)
• Michigan -13.5 (-111) vs Michigan State; Total 39.5 (-110)
• North Carolina -6.5 (-121) @ UConn; Total 54.5 (Under -113)
• Oklahoma State -3.5 (-107) @ Kansas State; Total 61.5 (Over -114)
• Texas -2.5 (-114) @ Missouri; Total 44.5 (Under -113)
• Tulsa -1.5 (-113) @ Tulane; Total 49.5 (Over -114)
• Kansas -2.5 (-125) vs UCF; Total 48.5 (Under -116)
• UCLA -6.5 (-108) vs Minnesota; Total 39.5 (-110)
• Duke -5.5 (-121) @ NC State; Total 50.5 (-110)
• Purdue -6.5 (-110) vs Maryland; Total 57.5 (-110)
• Auburn -10.5 (-111) vs Arkansas; Total 50.5 (Over -111)
• Delaware -2.5 (-113) @ Kennesaw State; Total 55.5 (Under -115)
• Washington -2.5 (-107) vs Penn State; Total 44.5 (Under -111)
• South Carolina -7.5 (+101) vs Texas A&M; Total 51.5 (Under -113)
• LSU -5.5 (-109) vs Alabama; Total 52.5 (Under -115)
• Ohio State -7.5 (-105) vs Oregon; Total 48.5 (Under -113)
• Texas Tech -17.5 (-103) vs West Virginia; Total 63.5 (Under -113)
• Western Kentucky -1.5 (-101) @ Middle Tennessee; Total 53.5 (Under -113)
• Tennessee -6.5 (-113) vs Kentucky; Total 51.5 (Under -113)
• Army -3.5 (-105) vs Air Force; Total 48.5 (-110)
• Georgia -3.5 (-110) @ Ole Miss; Total 56.5 (Over -112)
• Louisville -14.5 (-110) @ Georgia Tech; Total 60.5 (Under -111)
• Notre Dame -4.5 (-117) vs Miami; Total 57.5 (Over -114)
• Florida -6.5 (-110) vs Oklahoma; Total 45.5 (-110)
• Fresno State -2.5 (-111) @ Utah State; Total 42.5 (Under -113)
• Oregon State -6.5 (-115) vs Texas State; Total 69.5 (Under -111)
• UNLV -7.5 (+103) vs Wyoming; Total 47.5 (Over -113)

CFB W10 Early Best Bet: Notre Dame Fighting Irish -4.5 over Miami Hurricanes (-117)

Marcus Freeman and the Fighting Irish may not admit it out loud, but I’d be willing to bet a lot of money that the Notre Dame locker room has had this game circled for almost a year. I’m sure you would, too. Getting this game in South Bend only helps the Irish from a situational perspective. 

Oddsmakers have the top team in the country as more than a field-goal underdog on the road in this matchup, which is a strong indication of Notre Dame’s edge in their power ratings. It makes sense, the ‘Canes haven’t been looking completely invincible lately despite the undefeated record. They really could have lost at home to Florida State, and last week’s game in Chapel Hill was too close for comfort. Now on the road for the second straight week, this time against a program and fan base that has it out for you after being snubbed from last season’s playoff, the sloppy mistakes will likely be punished by the Irish. 

Miami’s defense isn’t perfect this year. The Hurricanes have struggled in the secondary, and they haven’t stuffed the run as efficiently as last year. Penalties have also been an issue for Mario Cristobal’s squad, as they rank 91st nationally in that regard, where Notre Dame is #1 in the country. 

Notre Dame usually takes money no matter what, so it wouldn’t surprise me to see -6 pop at some point. I’m fine with it up to that point, as I’m looking for an Irish win in the ballpark of 7-10 points.