Los Angeles Angels vs New York Yankees Prediction, Odds and Picks for Today, 04/16/26

After the Angels took the series opener 7-1 on Tuesday and the Yankees responded with a 5-4 win on Tuesday, Los Angeles and New York are set for an afternoon rubber match on Thursday in the Bronx. The previous 2 games of this mid-week series have stayed under the total, but it would be a bit surprising to see that trend continue in the finale. Los Angeles has yet to name a starting pitcher as of this publishing, which means it’s likely they use a plethora of pitchers in what ends up being a bullpen game. That’s been an area of weakness for the Angels in recent seasons, and this year is no different so far. The Los Angeles bullpen currently ranks 21st in ERA (4.74) and 25th in WHIP (1.55). That doesn’t give me much confidence that they will be able to completely shut down New York’s lineup.

Left-hander Max Fried is set to take the hill for the home team. Fried has been steady early on in 2026, as he enters this contest owning a strong 1.93 ERA and 0.75 WHIP through 4 starts and 28.0 innings of work. However, he could face some problems going up against a Los Angeles lineup that has hit lefties well to start the season. The Angels own a solid .768 OPS against southpaws so far this season, which is good for 6th in the league. After seeing 8 and 9 total runs scored in the first 2 games of this series, look for this game to be a bit more high-scoring.

Angels vs Yankees prediction: Over 9.5 (-110) available at time of publishing. Playable at that number.

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