Los Angeles Dodgers vs Houston Astros Prediction, Odds and Picks for Today, 05/06/26

The Houston Astros are in a downturn this season, sitting at 15-22 and fourth in the American League West, but the recent struggles of the Los Angeles Dodgers offense continued on Tuesday night with the Astros winning 2-1 to even the series at one game each. The rubber match goes down on Wednesday afternoon, with Tyler Glasnow facing off with Lance McCullers Jr.

Glasnow has been a bright spot once again for the Dodgers this season, owning a 3-0 record with a 2.56 ERA and a 0.83 WHIP. Things got away from him in his last start against the Miami Marlins, as he allowed just two earned runs on three hits but allowed six walks in the process. Glasnow does have some control issues pop up from time to time, but he normally sorts them out quickly.

It hasn’t been quite as successful a season for McCullers Jr, as he owns a 6.32 ERA with a 1.40 WHIP. The righty has never fully recovered from the injuries that caused him to miss the 2023 and 2024 seasons, while also battling through setbacks during the 2025 season. The Astros are hopeful that his form will return, but it’s acceptable to take some time after such a lengthy absence.

Nevertheless, the Dodgers need a struggling pitcher to attempt to get back on track, and I think they do it here.

Dodgers vs Astros prediction: Dodgers -1.5 (-130) available at time of publishing. Playable to that number.