Minnesota Twins vs Cleveland Guardians Prediction, Odds and Picks for Today, 04/30/25

The Minnesota Twins picked up the 11-1 victory in Monday’s series opener behind RHP Bailey Ober, while the Cleveland Guardians bounced back with a 2-1 win Tuesday night. These teams will square off in the third contest of a four-game set Wednesday. Veteran RHP Pablo Lopez looks to stay hot in his fifth start of the season. He has posted a 2-1 record with 2.08 ERA and 1.11 WHIP across 21 2/3 IP in four starts. He has been even better on the road, posting a 1.62 ERA and 1.02 WHIP while striking out 14 batters across just 16 2/3 IP in three starts away from home.

The Guardians counter with LHP Luis Ortiz, who is making his sixth start of the season. The results have been mixed, going 2-3 with a 5.96 ERA and 1.56 WHIP across 25 2/3 IP. He has been a high strikeout pitcher, going for 31 Ks, but he has also allowed 26 hits and 14 walks in his five outings, and teams are hitting .255 against him. The Twins should be able to get back into the win column, as they’re likely to rack up plenty of base runners against him. Let’s back the visitors for Game 3 of this four-game series.

Twins vs Guardians prediction: Twins ML (-130) available at time of publishing. Playable to -140.

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