Minnesota Twins vs Washington Nationals Prediction, Odds and Picks for Today, 05/06/26

The Minnesota Twins made a statement in their series opener with an 11-3 win over the Washington Nationals and will look to keep that momentum going tonight. The Twins will send Bailey Ober to the mound who is 3-1 with a 3.55 ERA. For the Nationals, they’ll hand the ball to Miles Mikolas who is 0-3 with a 8.23 ERA. One of the biggest concerns for the Nationals heading into this matchup is Mikolas inability to go deep into his starts this season, and Washington has one of the league’s worst bullpen ERA (4.77). However, even though the Twins have a more reliable starter on the mound, they also have one of the league’s worst bullpen ERA, sitting at 5.26. 

Offensively, the Twins are averaging 4.7 runs per game in their last 10 and hitting .247 while the Nats are averaging 3.9 runs per game and hitting .198 in that same span. Even with the Twins bullpen struggling this season, Washington’s lineup hasn’t been too much of a threat in recent games. Ober has been terrific on the mound in his last three starts, striking out 15 and giving up just three earned runs in 18.1 innings pitched. If Ober can go at least six innings for the Twins, and limit the number of innings they’ll need to use their bullpen, that’ll put Minnesota in a great position to pick up the win. The Twins should have no issues scoring a few runs against Mikolas early on, and I expect them to add a few more on late in the game against this Nationals bullpen. Look for the Twins to take care of business on Wednesday, making them my best bet of the day. 

Twins vs Nationals prediction: Twins ML (-135) at the time of publishing. Playable up to -145.