New York Yankees vs Boston Red Sox Prediction, Odds and Picks for Today, 04/21/26

The Boston Red Sox haven’t had the start to their season that they might have wanted, but they have been known to turn things around when the New York Yankees come to town to renew one of the greatest rivalries in sports. The Red Sox currently sit in last place in the American League East with a 9-13 record, but the Yankees aren’t too far out of their sights at 13-9. Boston’s 9 consecutive games against division rivals over the next 9 days could make or break their season. The Red Sox do have the pitching edge in this game, as Connelly Early takes the mound against Luis Gil. Early has been even better in 2026 than his incredible beginning to last season. Early owns a 2.29 ERA over the 4 starts compared to his 2.33 mark last year.

Gil has been struggling with his control this season and has also been unable to get himself out of jams. He lasted just 9.0 innings over 2 starts, allowing 7 earned runs and 5 walks. Boston’s offense exploded for 8 runs against the Detroit Tigers during Monday afternoon’s Boston Marathon game, which could be bad news for the Yankees this week if they are getting hot. The bad news for the Red Sox is that their lineup hasn’t had much success against Gil in their careers, and they combined for just 4 runs over the first 3 games against the Tigers. The Red Sox and Yankees have some great offensive matchups over their history, but this one could be a low-scoring battle.

Yankees vs Red Sox prediction: Under 8.5 (-115) available at time of publishing. Playable at that number. 

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