Philadelphia Phillies vs Chicago Cubs Prediction, Odds and Picks for Today, 04/20/26

Monday’s meeting between the Philadelphia Phillies and Chicago Cubs is a matchup between 2 teams going in opposite directions right now. On one side, the Phillies are enduring a tough start to the season and enter this matchup riding a 5-game losing streak. On the other side, the Cubs are riding high and bring a 5-game winning streak into this contest. These teams met last week in Philadelphia, and the Cubs took 2 out of 3 with the 2 wins coming by scores of 11-2 and 10-4. That should give them plenty of confidence to keep the momentum rolling.

Aaron Nola will take the mound for the Phillies, and he is coming off a start in which he allowed 8 hits and 3 runs over 5.0 innings to the Cubs on Tuesday. Nola struggled in 17 starts last season, posting a 6.01 ERA and 1.35 WHIP through 94.1 innings, and he is off to a rough start in 2026. The Cubs rank 6th in baseball with a team OPS of .739, so Nola could have his hands full once again. With the way they are rolling right now, the Cubs are the team to back in this National League matchup.

Phillies vs Cubs prediction: Cubs ML (-115) available at time of publishing. Playable at that number.

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