Pittsburgh Pirates vs Arizona Diamondbacks Prediction, Odds and Picks for Today, 05/06/26

The Pittsburgh Pirates and Arizona Diamondbacks have the potential for a great series this week, as both teams sit with nearly identical records. However, the Diamondbacks made quick work of the Pirates in the first game of the series, jumping out to an early 2-0 lead and running away with a 9-0 victory. The tides could turn for Wednesday night’s matchup, as Paul Skenes will take the mound against Michael Soroka.

Skenes had a great start to April, registering 5 consecutive starts with 1 earned run or fewer, including shutouts in the final 2 games of that stretch. However, he went back to his struggles from the start of the season in the final start of the month, allowing 7 hits, 2 of them home runs, in just 5 innings of work.

The good news for the Pirates is that Soroka is also coming off a brutal showing in his most recent outing. He allowed 10 hits and 8 earned runs over just 3 innings. Soroka does have some good outings this season, but his inconsistency is concerning at best. With Skenes motivated to bounce back, and the Pirates themselves sour about Tuesday result, expect Pittsburgh to get a win back in this one.

Pirates vs Diamondbacks prediction: Pirates ML (-130) available at time of publishing. Playable to that number. 

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