San Diego Padres vs Los Angeles Angels Prediction, Odds and Picks for Today, 04/17/26

Matt Waldron is set to make his season debut for San Diego with Nick Pivetta moving to the injury list, marking the right-hander’s second Major League start since the 2024 season. Waldron made 3 rehab appearances following surgery in February and tossed 12.0 scoreless innings with a 12-to-1 strikeout-to-walk ratio. While it might be tough to rely on an arm we haven’t seen in practically 2 years, the Padres’ bullpen is arguably the best in MLB at the moment — posting a combined 2.89 ERA, including closer Mason Miller’s perfect 0.00 ERA mark. 

Offensively, no team in the league has been able to match the output San Diego has produced throughout its 8-game winning streak. The Padres are posting a 151 wRC+, a .300 BA as a team and a .401 xwOBA over the last 7 days. Los Angeles starter Jose Soriano (0.33 ERA, 0.67 WHIP) has been incredible thus far, but this is easily the best lineup he has faced to date this season and the Angels’ bullpen hasn’t exactly been reliable. At a plus-money price, I’ll back San Diego to continue its surge.

Padres vs Angels prediction: San Diego ML (+120) available at time of publishing. Playable at that price.

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