St. Louis Cardinals vs San Diego Padres Prediction, Odds and Picks for Friday, 05/08/26

With a 2-1 victory over the Padres last night, the St. Louis Cardinals continue to be one of the hottest teams in baseball. They’ve now won 8 of their last 10 games, and in that span, they’re averaging 5.1 runs and hitting .245. For the San Diego Padres, it’s been a different story, losing 6 of their last 10, averaging 4.0 runs and hitting .220. 

Taking the mound for the Cardinals will be Michael McGreevy, who is 2-2 with a 2.52 ERA and a 0.92 WHIP through 7 starts. To counter, the Padres will hand the ball over to Griffin Canning, who will be making his 2nd start of the season. In his first start against the White Sox, he allowed just 1 run on 3 hits while striking out 7 in 5 innings pitched.

One of the biggest issues for the Padres right now is their offense. Their hitters are simply underperforming, as Manny Machado is hitting .214 in his last 11 games, Ramon Laureano is around .143 and Xander Bogaerts hitting .250 in his last 12. With the Padres struggling offensively and the Cardinals being one of the hottest teams in baseball — in addition to 12-5 on the road — there’s a lot of value with them as underdogs. Look for the Cardinals to get things done behind McGreevy.

Cardinals vs Padres prediction: St. Louis Cardinals ML (+125) at time of publishing. Playable to +115.

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