Toronto Blue Jays vs Tampa Bay Rays Prediction, Odds and Picks for Today, 05/04/26

The Tampa Bay Rays enter the new week in a groove. Tampa Bay has won 9 of its last 10 games, and have been great at home throughout the first 5 weeks of the season. Owning a record of 11-4 at Tropicana Field to start the 2026 campaign, the Rays should enter this Monday night matchup against the Blue Jays with plenty of confidence. Nick Martinez is slated to take the mound in this one, and he has allowed 2 or fewer earned runs in each of his first 6 starts this season. The Rays are 5-1 in those games.

On the other side, the Blue Jays head to Tampa after splitting a 4-game series with the Twins in Minnesota over the weekend. The Blue Jays have had their struggles on the road early on this season, as they are just 6-10 away from Toronto. Starting pitcher Eric Lauer is off to a rough start. He enters this matchup with a 6.00 ERA and 1.52 WHIP over 6 starts. The Blue Jays are just 2-4 in those starts, and things won’t get any easier as they go up against the red-hot Rays on the road. Ride the hot hand and back the Rays on the moneyline in this one.

Blue Jays vs Rays prediction: Rays ML (-105) available at time of publishing. Playable to -110.