2022 NFL preview: San Francisco 49ers futures, Super Bowl odds, predictions and best bets

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Keith

NFL · 2 weeks ago

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A Bostonian with a love for stats and baseball. Using knowledge and passion to find the right bet in MLB, NBA, NFL, and more. A lover of bold sports takes and sweat free plus odds picks.

It will be a new era in San Francisco in 2022 as Trey Lance will take over as quarterback. Jimmy Garoppolo will be replaced, and the veteran could be on the move before the season begins. The 49ers have a lot of potential, but are there holes in their offense that could lead to their downfall? There certainly will be if San Francisco can’t reach a deal with Deebo Samuel, which still remains a top priority for the 49ers. They had a solid season in 2021, so let’s see what they can do in 2022.

San Francisco 49ers breakdown

2021 record: 10-7

2022 ATS record: 9-8

2021 O/U record: 8-9

Key players in: Ray-Ray McCloud (WR), Charvarius Ward (CB)

Key players out: Raheem Mostert (RB), Laken Tomlinson (G), Mohamed Sanu (WR)

2022 NFL Draft class: Drake Jackson (LB), Tyrion Davis-Price (RB), Danny Gray (WR), Spencer Burford (OT), Samuel Womack (CB), Nick Zakelj (OT), Kalia Davis (DT), Tariq Castro-Fields (CB), Brock Purdy (QB)

San Francisco 49ers 2022 NFL season odds

Odds provided by DraftKings Sportsbook

San Francisco 49ers Super Bowl odds

The 49ers are +1600 to win Super Bowl LVII, which has them as the eighth favorites. Only the Buffalo Bills, Tampa Bay Buccaneers, Green Bay Packers, Kansas City Chiefs, Los Angeles Rams, Los Angeles Chargers and Denver Broncos are ahead.

San Francisco 49ers NFC Championship odds

San Francisco is +750 to win the conference. The 49ers trail only Tampa Bay (+350), Green Bay (+400), and Los Angeles (+450).

San Francisco 49ers NFC West odds

At +150, the 49ers are second favorites to win the NFC West. The Los Angeles Rams are favorites at +125.

San Francisco 49ers win total odds

The 49ers’ win quota is 10 games. Under 10 is the favorite at -120, while the over comes with +100 odds. San Francisco is expected to make the playoffs at -225, but if you are willing to risk a bet on the 49ers to miss the playoffs, that would pay out at +175 odds.

Head to our NFL Odds page for odds on all the main NFL betting markets

San Francisco 49ers Schedule 2022

at Chicago Bears – Sunday, September 11
vs Seattle Seahawks – Sunday, September 18
at Denver Broncos – Sunday, September 25

vs Los Angeles Rams – Monday, October 3
at Carolina Panthers – Sunday, October 9
at Atlanta Falcons – Sunday, October 16
vs Kansas City Chiefs – Sunday, October 23
at Los Angeles Rams – Sunday, October 30

BYE
vs Los Angeles Chargers – Sunday, November 13
at Arizona Cardinals – Monday, November 21
vs New Orleans Saints – Sunday, November 27

vs Miami Dolphins – Sunday, December 4
vs Tampa Bay Buccaneers – Sunday, December 11
at Seattle Seahawks – Thursday, December 15
vs Washington Commanders – Saturday, December 24

at Las Vegas Raiders – Sunday, January 1
vs Arizona Cardinals – TBD

We’ll have NFL picks for EVERY matchup of the 2022 season

San Francisco 49ers 2021 season recap

After a mediocre start to their 2021 season, the 49ers closed their regular season on a 7-2 run and made it to the NFC Championship game. A 20-17 loss to their divisional rivals the Rams ended the Niners’ season, and it was time for San Francisco to answer some tough questions. Who will be the quarterback in 2022? Is Trey Lance ready? Will Deebo Samuel even be on the team? Samuel emerged as one of the best offensive weapons in football as he was used out wide as a receiver, but also in the backfield. This allowed Samuel to combine for 14 touchdowns in 2021 (8 rushing and 6 receiving) and carry the San Francisco offense.

But once the season was over, Samuel requested a trade from San Francisco as he did not like the way head coach Kyle Shanahan was using him in the backfield. The 49ers are still trying to reconcile with Samuel and are engaging in a short-term contract. As for the rest of the team, Brandon Aiyuk was disappointing in his second season with only 56 receptions for 836 yards, Lance started only 2 games and finished with 5 touchdowns and 2 interceptions, and RB Elijah Mitchell blossomed in Raheem Mostert’s absence.

Read our Super Bowl 57 predictions and best bets, including a +4500 longshot

San Francisco 49ers 2022 NFL season predictions

Shanahan has made it clear that Lance will be the starting quarterback of the 49ers this season. They will also attempt to trade Garoppolo in the next few weeks. However, there are still a lot of questions that remain: will the Niners make amends with Samuel, or will they lose their best offensive threat? If San Francisco loses Deebo, that will put even more pressure on Lance because he will be without a true No. 1 receiver. The rest of the Niners’ receiving core is very average, and it could cause Shanahan to put more emphasis on Mitchell, who had a breakout 2021 campaign.

One question that won’t need to be answered is their defense, which is projected to be a top-5 unit in the NFL. Led by Nick Bosa and Fred Warner, the 49ers’ defense should once again be their strong suit in 2022. San Francisco has one of the more difficult schedules in 2022 as they play the Rams, Buccaneers, Chiefs, Broncos and Chargers, among many other solid teams. It won’t be easy, especially with an inexperienced quarterback at the lead.

Best bet: San Francisco 49ers under 10 wins (-120)

There are many uncertainties about the Niners in 2022, and for that reason, I’m pessimistic about them. Lance was incredible in college, but he’s had only 2 NFL starts and wasn’t impressive in either one. If he loses Samuel, he would have to rely on tight end George Kittle as his safety blanket, which can get predictable, and the tight end has a suspect injury record too. In 2020, he sprained his MCL and broke a bone in his foot which caused him to miss a considerable amount of time, and he missed action in 2021 due to a calf strain and knee strain. The 49ers’ defense will do their part, but there’s too much risk and not enough reward with the Niners this season, so I don’t expect them to finish with 11 or more wins.

San Francisco 49ers season record predictions

Based on their schedule, I see a 9-8 season for the 49ers in 2022. A lucky win could get them to 10-7, but even then, this bet would push, and you’d get your money back. Don’t expect them to win 11 games. 

Find out which QBs we’re targeting for our NFL MVP best bets

Pickswise is the home of free expert NFL Picks and NFL Odds. Be sure to check out all of our season previews and NFL Futures Bets leading up to the 2022 NFL season.

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