NFL Week 5 same game parlay (+979): San Francisco 49ers vs Arizona Cardinals

Cardinals' Kyler Murray (1) warms up with Deandre Hopkins (10) before a game against the Eagles at State Farm Stadium in Glendale, Ariz. on Dec. 20, 2020.
Photo of Ricky Dimon

Ricky Dimon


Show Bio

Since graduating from Davidson (The College That Stephen Curry Built), I have been writing about sports -- just about any and all you can think of! -- and coaching tennis in Atlanta, GA. Beyond the four major sports, I am an avid tennis fan and cover the ATP Tour on a daily basis. If I'm not busy writing, you can generally find me on a tennis court or traveling the world wherever a sporting event takes me. For Ricky Dimon media enquiries, please email
Read more about Ricky Dimon

The Arizona Cardinals are the last undefeated team remaining in the NFL and they will try to stay that way when they host the NFC West rival San Francisco 49ers in Week 5. Let’s take a look at the best same game parlay option for 49ers-Cardinals, and also be sure to check out our full game preview for picks on the side and total.

Arizona Cardinals -9.5 alternate spread (+230)

DeAndre Hopkins to score 2+ touchdowns (+500)

Parlay odds: +979

Part of the value in same game parlays, of course, is that all of its components can be correlated if you so choose. That is the entire plan here, as DeAndre Hopkins scoring multiple touchdowns would obviously work extremely well with an Arizona win. Let’s break down each of the two legs.

Arizona Cardinals -9.5 alternate spread (+230)

The Cardinals’ perfect record is bookended by especially impressive results, starting with a 38-13 shellacking of Tennessee and most recently a 37-20 win over the previously undefeated Rams. The Week 4 game wasn’t even as competitive as the score suggests, as Arizona led 37-13 before surrendering a meaningless touchdown with 1:14 remaining. Kyler Murray has established himself as the MVP favorite (+450) with 1,273 passing yards and 13 total touchdowns.

It goes without saying that the 49ers’ quarterback situation is less stable. Jimmy Garoppolo is out with a calf contusion, which means rookie Trey Lance will make his first-ever NFL start. San Francisco has lost two in a row at the hands of Green Bay and Seattle following wins over Detroit and Philadelphia. Things are going south in the Bay Area, and it’s hard to see them turning it around against arguably the best team in the league. San Francisco is 4-9 ATS in its last 13 overall and 2-5 ATS in its last 7 following a loss. The Cardinals are 5-1-1 ATS in the last 7 meetings between the teams. Arizona should cover 5.5 points and it has a good chance to prevail by double-digits.

DeAndre Hopkins to score 2+ touchdowns (+500)

We will likely need the Cards to cook up a lot of points to win by at least 10, of course. If that happens, Hopkins has to be effect. And there is no reason why he can’t be. The 49ers have surrendered at least 28 points in 3 of its 4 games this season, including 33 to winless Detroit. They have made only 1 interception and cornerback K’Waun Williams is questionable after missing last week’s game. Arizona has scored at least 31 points in all 4 of its contests and leads the league with 140 total points. Hopkins has scored 3 of the TDs and he already boasts one 2-touchdown effort (in Week 1 against Tennessee). Don’t be shocked if he accomplishes the feat a second time.

Pickswise is the home of free NFL Predictions  and NFL Odds. Check out the latest NFL Prop Bets and NFL Parlays as well as expert NFL Underdog Picks and NFL Computer Picks

By signing up you agree to our terms and privacy policy