NFL Week 16 picks and predictions - Millionaire maker 14-team money line parlay at +129424 odds: Vikings are vulnerable against Giants

New York Giants running back Saquon Barkley (26) celebrates his touchdown with guard Jon Feliciano (76) during the first half against the Washington Commanders at MetLife Stadium.
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Ricky Dimon

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Since graduating from Davidson (The College That Stephen Curry Built), I have been writing about sports -- just about any and all you can think of! -- and coaching tennis in Atlanta, GA. Beyond the four major sports, I am an avid tennis fan and cover the ATP Tour on a daily basis. If I'm not busy writing, you can generally find me on a tennis court or traveling the world wherever a sporting event takes me. For Ricky Dimon media enquiries, please email contact@pickswise.com.

Week 16 of the 2022 NFL season is getting underway with Thursday Night Football between the Jacksonville Jaguars and New York Jets, but now it’s time to look ahead toward the weekend schedule. The Saturday (11) and Sunday (3) slates features a sizable total of 14 games, with some massive playoff implications at hand. Each week we are choosing a millionaire parlay, picking every game on the money line for the chance at a massive payday.

Without further ado, here is our 14-leg Week 16 millionaire parlay. It would pay out at +129424 odds! How about a Christmas miracle?!?!

Make sure to check out our NFL Week 16 picks for EVERY matchup!

Buffalo Bills ML (-365) over Chicago Bears

It’s not the biggest spread of the week, but it’s close. Give me the Bills without any hesitation.

Check out our full Bills vs Bears predictions

Cincinnati Bengals ML (-170) over New England Patriots

The Bengals are on an absolute roll right now and it’s going to be hard for the Patriots to recover from last week’s complete final-play disaster.

Check out our full Bengals vs Patriots predictions

Kansas City Chiefs ML (-460) over Seattle Seahawks

This is the biggest spread of Week 16, with Kansas City favored by 10 points. Needless to say, the money line should be extremely safe.

Check out our full Chiefs vs Seahawks predictions

New York Giants ML (+180) over Minnesota Vikings

If any 11-3 team in this history of football cannot be trusted, it’s these Vikings. They have played with fire so often in 2022 that eventually they will get burned.

Check out our full Giants vs Vikings predictions

Carolina Panthers ML (+120) over Detroit Lions

This is one of the toughest calls of the week, but I will go with the Panthers at home at plus money. The Lions’ hot streak has to end at some point, right?

Check out our full Lions vs Panthers predictions

Tennessee Titans ML (-165) over Houston Texans

You have to give Houston credit for not throwing in the towel. The Texans will probably be competitive yet again, but I’m not prepared to pick an outright win.

Check out our full Texans vs Titans predictions

Cleveland Browns ML (-155) over New Orleans Saints

Is anyone going to spend Christmas Eve watching Cleveland vs New Orleans?!?! Outside of the 2 cities and perhaps a few fantasy owners with playoff implications, no! Whatever the case, let’s go with the Browns.

Check out our full Saints vs Browns predictions

Baltimore Ravens ML (-325) over Atlanta Falcons

Both teams are on their 2nd quarterbacks. That’s a bigger deal for Baltimore since Lamar Jackson is a lot better than Marcus Mariota, but the Ravens’ supporting cast is much better than that of the Falcons.

Check out our full Falcons vs Ravens predictions

San Francisco 49ers ML (-340) over Washington Commanders

Washington’s offense isn’t good even against bad defenses. Now it has to face San Francisco, so points will likely be few and far between for the visitors.

Check out our full Commanders vs 49ers predictions

Dallas Cowboys ML (-245) over Philadelphia Eagles

The good news for the Cowboys is they’ll probably win since Jalen Hurts is out; the bad news is it probably won’t matter in the division race because of last week’s loss to Jacksonville.

Check out our full Eagles vs Cowboys predictions

Pittsburgh Steelers ML (-135) over Las Vegas Raiders

Neither team inspires much confidence, but I’ll throw my eggs into the Mike Tomlin basket over the Josh McDaniels basket any day of the week. Yes, even Saturday.

Check out our full Raiders vs Steelers predictions

Green Bay Packers ML (+165) over Miami Dolphins

Three games are saved for Christmas Day, starting with the Packers visiting the Dolphins. Even though this isn’t in the Frozen Tundra, Aaron Rodgers and company can’t be counted out.

Check out our full Packers vs Dolphins predictions

Los Angeles Rams ML (+130) over Denver Broncos

This is a matchup of which only Ebenezer Scrooge would approve. Actually, some bettors also might approve. After all, getting any Denver opponent at +130 is an enticing play.

Tampa Bay Buccaneers ML (-360) over Arizona Cardinals

Someone has to win a clash between 2 of the most disappointing teams in the league. And when it’s Tom Brady with a team still in contention vs Colt McCoy with a team out of contention, it’s a no-brainer.

Check out all of our NFL Week 16 predictions

Pickswise is the home of free NFL Picks and NFL Odds. Check out the latest NFL Prop Bets and NFL Parlays as well as expert NFL Underdog Picks and NFL Computer Picks.

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