NFL Week 5 picks and predictions - Millionaire maker 13-team money line parlay at +60295 odds: Texans win again

San Francisco 49ers quarterback Brock Purdy (13) runs onto the field before a wild card game against the Seattle Seahawks at Levi's Stadium.
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Phil Agius


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I've been writing about the NFL and a host of other sports for the UK's top daily betting paper the Racing Post for more than 20 years. An incurable Browns fan (1-31 survivor), I also specialise in all kinds of motorsport betting including F1, MotoGP, IndyCar and NASCAR. For Phil Agius media enquiries, please email

NFL Week 5 slate started with an upset as the Bears won for the first time in almost a year by beating the Commanders on Thursday Night Football. One of the most fun bets you can have with an NFL wager is to swing for the fences with a millionaire parlay, so I’ve taken a money line pick from every remaining game this week to create this huge +60295 odds parlay.

With the bye weeks beginning this week and the Browns, Chargers, Seahawks and Buccaneers taking an early rest, our mission is slightly less impossible than it has been in the first 4 weeks as we need a mere 13 wins to hit the jackpot. Let’s see the teams that could make us rich across Sunday and Monday night. Make sure to also check out our NFL Week 5 picks for EVERY matchup!

Buffalo Bills ML over Jacksonville Jaguars (-235)

The nightmare scenario is that this bet flops even before Sunday lunch as the Bills and Jags are playing at 9:30 am ET in London (but if that happens, you can cover the other 12 games in a new bet!). The Bills looked back to their best against the Dolphins last week, and though the Jaguars are playing across the pond for a second straight week, they are not the official home team this time and will be playing at a different stadium too, so the benefits are reduced.

Check out our full Jaguars vs Bills predictions

Houston Texans ML over Atlanta Falcons (+108)

You might not expect the Texans to go into many games this season with the better quarterback but that looks the case as CJ Stroud battles Desmond Ridder. The Texans look one of the better underdogs this week as DeMeco Ryans has really got them playing well. The Falcons have had no bye week after flying in from London, either.

Check out our full Texans vs Falcons predictions

Detroit Lions ML over Carolina Panthers (-490)

This is one of the more open-and-shut cases of the week. Dan Campbell will be biting some of his own players’ kneecaps if they can’t beat the 0-4 Panthers. His team gets a further boost this week now WR Jameson Williams’ suspension is over.

Check out our full Panthers vs Lions predictions

Indianapolis Colts ML over Tennessee Titans (+116)

This is one of the closer calls on the slate, so I’m happy to take the Colts as home dogs. The Titans are 0-2 on the road and the outlook is finally looking a little brighter for Indy.

Check out our full Titans vs Colts predictions

Miami Dolphins ML over New York Giants (-700)

Ours won’t be the only parlay that goes down if the Giants beat the Dolphins this week. The Big Blue has big problems at the moment and the Miami offense could run up the score.

Check out our full Giants vs Dolphins predictions

Baltimore Ravens ML over Pittsburgh Steelers (-196)

The Ravens dominated against the Browns’ backup QB last week but it shouldn’t really make much difference whether Steelers starter Kenny Pickett is able to play or not. Pittsburgh’s issues seem to be more widespread.

Check out our full Ravens vs Steelers predictions

New England Patriots ML over New Orleans Saints (-106)

Here we have two teams you wouldn’t want to back against most others, but someone has to win. It may well be the Patriots, with the Saints seemingly getting worse each week, while New England’s losses have at least been to stronger teams.

Check out our full Saints vs Patriots predictions

Cincinnati Bengals ML over Arizona Cardinals (-172)

Here’s another game you would ideally want to leave out of any parlays this week, but that’s not in the rules of this article, so we’ll go for the Bengals, whose season would just about be over if they can’t win this one and fall to 1-4.

Check out our full Bengals vs Cardinals predictions

Philadelphia Eagles ML over Los Angeles Rams (-215)

This pick isn’t the layup it might have looked like a few weeks ago as the Eagles still haven’t hit top gear while the Rams have been much better than advertised. The Eagles have been getting the job done one way or another though and that could be the case again.

Check out our full Eagles vs Rams predictions

Kansas City Chiefs ML over Minnesota Vikings (-190)

I’d prefer to play the over in this potential fast-track shootout than either team’s money line, but will stick with the Super Bowl champions to prevail against this exciting but flawed Vikings team.

Check out our full Chiefs vs Vikings predictions

New York Jets ML over Denver Broncos (+116)

The Nathaniel Hackett revenge game is here and the Jets OC has the weapons to pull it off against his former team. He could perhaps even afford the odd Zach Wilson turnover and still get the W in this grudge match against Sean Payton. This is definitely one of the stronger underdog plays of the week.

Check out our full Jets vs Broncos predictions

San Francisco 49ers ML over Dallas Cowboys (-184)

The new top team in the Pickswise NFL Power Rankings can show why that status was earned against the inconsistent Cowboys. This SNF matchup is the most enticing of the week but the 49ers look capable of beating anyone at the moment.

Check out all of our Cowboys vs 49ers predictions

Green Bay Packers ML over Las Vegas Raiders (-102)

The Raiders have had a tough schedule to start the season but an unhappy home crowd could work against them on Monday night as they struggle to meet expectations. The Packers are getting healthier and can further darken the mood of the Black Hole.

Check out all of our Packers vs Raiders predictions

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