This Week's Hottest Trends: 5 best trends for betting NFL Week 10

Sean Payton
Photo of Andrew Ortenberg

Andrew Ortenberg

NFL· 3 weeks ago

Show Bio

I'm an editor here at Pickswise who was raised in a household full of sports fanatics. Since I unfortunately never had LeBron James' jumping ability I wasn't able to make it to the NBA, and chose writing about sports as the next best thing. An avid sports bettor myself, I'm excited to get to write about the industry as it gets set to take off across the country. Buckle up.

The first couple of months of the NFL season have been thrilling, and Week 10 has just as much potential. We will, of course, have free picks on the side and total for every game that you can view in our NFL picks tab. But right now, we’re talking trends.

Trends can be very important and tell you a lot, or they can be completely insignificant. It’s all about parsing what actually matters, and which ones might reveal something not already being factored into the point spread. Here are our top 5 trends to help you make your Week 10 NFL wagers.

Road ‘dogs seize another week

The betting story of this NFL season has to be the performance of road underdogs. Road teams have been doing well and underdogs have been doing well, so it’s only fitting that road ‘dogs have been dominant. They went 8-2 ATS in Week 9, bringing them to 51-31-1 for the year. That’s a cash rate north of 62 percent. There was a lot of talk this offseason about the return of fans potentially giving home teams an advantage.

Not only has that not materialized, the opposite has been true. Home-field advantage just isn’t what it used to be. This week there are another nine road underdogs, and our experts are riding with six of them, so we certainly hope this trend continues for at least another week.

Road teams coming off a bye are 69-43-6 ATS since 2003

Speaking of road teams, this trend dates back to well before just this year. While road teams have been cashing left and right overall in 2021, they’ve been great off the bye over the past couple of decades. Road teams that are coming off their bye week are 69-43-6 against the number since 2003. That’s a cash rate north of 61 percent.

This week, three teams qualify. The Bucs will go on the road to face Washington (also coming off a bye, the Seahawks have a trip to Green Bay to take on the Packers, and the Lions will visit the Steelers. We’re rolling with all three of Tampa Bay, Seattle and Detroit, so once again we’re agreeing with this trend.

Mike Vrabel excels as an underdog, not so much as a favorite

Football is an emotional game. As such, a lot of teams seem to thrive when they have a chip on their shoulder. Some squads just rally around being an underdog, and excel in that role. As our very own Jared Smith pointed out on Twitter, that seems to be the case with Mike Vrabel and the Titans. Since taking over as head coach in Tennessee, Vrabel is 17-9 ATS as an underdog. But when he is laying points, he is just 14-17 ATS.

Last week the Titans were big underdogs against the Rams, and they emerged with the outright victory. This week, they’re home favorites against the Saints. Might the team be riding high off their win over the Rams and get caught slipping?

Teams coming off outright wins as underdogs of 10+ points are 1-7 ATS in their last 8 games when a double digit ‘dog the next week

This one is interesting, and it perhaps doesn’t bode well for the Jacksonville Jaguars. The Jags are riding high off their massive upset over the Bills, where they won outright as an underdog of more than two touchdowns. But huge wins like that can often lead to letdown spots the following week. And when teams who pull off a stunner like that and then find themselves just as big of an underdog the next week, things haven’t gone well.

The last eight times that teams have pulled off an outright upset as underdogs of 10+ points and have then been underdogs of 10+ points again the next week, they have gone just 1-7 against the spread. Jacksonville is a 10-point ‘dog this week against Indianapolis. I can’t wait to see whether head coach Urban Meyer’s team is able to build off its newfound momentum or if it falls flat.

Check out John Hyslop’s best underdog plays for Week 10

The Saints are 8-0-1 ATS in their last 9 games as an underdog

Vrabel has been great as an underdog, and so too has Sean Payton. It just so happens that they’re playing each other this week. This one also points toward New Orleans. The Saints have gone an eye-popping 8-0-1 ATS the last nine times they’ve been an underdog. Oddsmakers seem to be keenly aware of this trend, and are giving Payton all the respect he deserves.

The Titans have the best record in the AFC and have beaten the Chiefs, Bills, and Rams. The Saints are playing with Trevor Siemian at quarterback. And yet this spread is less than a field goal. That shows how scared oddsmakers are to take a position against Payton in these kind of spots. Doubting him usually hasn’t gone too well in the past.

Make sure you check out Pickswise Playbook, our new weekly NFL betting show with Chris Rose, Ross Tucker, and Jared Smith as they look to make your next bet better! Out every Thursday.

Pickswise is the home of free NFL Picks and NFL Odds. Check out the latest NFL Prop Bets and NFL Parlays as well as expert NFL Underdog Picks and NFL Computer Picks.

See All


Bet $10, Win $200 If Your Team Covers +40 Points!

Register for a new BetMGM account & deposit $10+

Bet $10 on your team to win Money Line

Win $200 in free bets if your team covers +40 points

21+. Terms & conditions apply.



Bet $20, Get $200 - Regardless of Outcome!

Register for a new PointsBet account & deposit $20+.

Bet $20 on any game in any sport!

As soon as your game is over, you'll receive a $200 bonus - no matter whether your initial bet won or lost!

Caesars Sportsbook


Get a $1,001 Free Bet + A FREE NBA JERSEY!

Register for a new Caesars Sportsbook account & make a deposit

Place your first bet up to $1,001

Win or lose, you'll receive a free bet matching your initial stake - up to $1,001! You'll also be given a gift card for a FREE NBA JERSEY!

21+. Terms & conditions apply.



Get a $250 Deposit Bonus!

Sign up for a new BetRivers account using promo code PICKSWISE

Make a deposit & get it doubled up to $250 total

To get a $100 bonus, deposit $100

Must be 21+. Play in IA Only. Gambling Problem? Call 1-800-BETS OFF



Get a $1,000 Risk Free Bet!

Register for a new BetMGM & deposit

Place your first bet up to $1,000 risk-free!

Get refunded up if you lose up to $1,000

21+. Terms & conditions apply.

FanDuel Sportsbook


Get a $1,000 Risk Free Bet!

Register for a new FanDuel Sportsbook account & deposit

Place your first bet up to $1,000 risk-free!

Get refunded up if you lose up to $1,000

21+. Terms & conditions apply.



Get a $1,000 Deposit Bonus!

Register for a new DraftKings Sportsbook account & deposit

DraftKings will match 20% of your deposit up to $1,000 total

To get a $100 bonus, deposit $500

21+. Terms & conditions apply.



Get a $500 Risk-Free Bet!

Register for a new Unibet account & make a deposit

Place your first bet up to $500 risk-free!

Get refunded up if you lose up to $500

New players only. Terms & conditions apply. 21+. VA only.

Monkey Knife Fight


Claim 100% Instant Deposit Match up to $100!

Register for a Monkey Knife Fight account & deposit using promo code PICKSWISE100

Monkey Knife Fight will match your first deposit up to $100

Deposit $100 and you'll get $100 bonus + a free $5 game

18+. Terms and conditions apply. You must live in one of the states where real money DFS is legal.



Get a $300 Risk-Free Bet with TVG Racebook!

Register for a new TVG account and make a deposit

Place your first single horse win-type bet up to $300

If your horse doesn't win you'll get a refund up to $300

21+. T&C's apply. Please gamble responsibly.

BetAmerica Racing


$200 Sign Up Bonus!

Fast, reliable and fast payouts - you'll have your money in 72 hours, if not sooner!

Proud history of providing safe, secure, and fun betting to American patrons

BetAmerica is owned by the iconic Churchill Downs Incorporated, home of 150 years of wagering history and the world-famous Kentucky Derby

Players who sign up using ‘BET200’ code will get a $200 sign up bonus. Offer valid for 7 days after registering on BetAmerica Racing product only. 21+. T&C's apply. Please gamble responsibly.



Get a $400 Risk-Free Bet on the Breeders' Cup!

Register for a new Twinspires account using offer code PICKS400

Place a bet on the Breeders' Cup

Receive a refund if your first bet loses up to $400

21+. T&C's apply. Please gamble responsibly.