Wise n' Shine: NFL and MLB picks with the PLL championship game for Sunday, September 18

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Lead MLB Writer for Pickswise. A Bostonian with a love for stats and baseball. Using knowledge and passion to find the right bet in MLB, NBA, NFL, and more. A lover of bold sports takes and sweat-free plus-odds picks. For Keith Schmelter media enquiries, please email contact@pickswise.com.

Good morning, Pickswise Nation. Week 2 of the NFL continues today along with a hefty slate of MLB game and the PLL championship game. Let’s get straight to making your next bet better.

About Last Night

College football best bests article was perfect AGAIN
We were a perfect 3-0 on our college football best bets article in Week 1, and guess what? We did it again courtesy of Caleb Wilfinger. His 3 college football best bets on Saturday finished 3-0 as Western Kentucky covered their +7 spread over Indiana, Penn State easily covered their -2.5 spread over Auburn and Ole Miss finished it off by covering their -16 spread over Georgia Tech.

Today’s Slate

NFL Week 2 continues
Thursday night football was just a taste of what’s in store for this weekend. Football is on all day on Sunday and the day concludes  with a Bears vs Packers Sunday Night Football matchup. Read all today’s NFL picks.

Don’t forget about baseball!
We have a full 15-game slate of MLB today. The White Sox and Tigers begin the day at 12:10 pm ET, while Sunday Night Baseball features Dodgers vs Giants at 7:08 pm ET on ESPN. Check out our MLB predictions.

Premier Lacrosse League Championship is HERE!
It’s been a long season in the PLL and it all comes down to today. The Waterdogs and Chaos are the last two teams standing and they will face off in the championship game at 3:00 pm ET. Check out our prediction for the PLL championship game.

Best Bet of the Day

NFL: San Francisco 49ers -9.5 vs Seattle Seahawks
4:05 pm ET, FOX

This game looks the ideal “buy low, sell high” opportunity on the board in Week 2. The 49ers melted in the second half against the Bears and Trey Lance did not look the part, grading out as the second-worst QB in Week 1, just behind Dak Prescott. Lance’s -19% CPOE (completion percentage over expectation) was the worst mark of his career. The good news is he’ll be back at home this week facing a Seahawks defense on short rest and without their best player, Jamal Adams. Despite holding the Broncos to just 16 points on Monday, the analytics were ugly and Seattle’s defense had the 4th-lowest EPA per play of any team in Week 1.

Check out our full 49ers vs Seahawks preview.


Don’t forget to check out our daily show Let’s Bet It on our YouTube channel at youtube.com/c/Pickswise at 10:00 am ET.

Jared Smith & Mark Zinno are your hosts today and they will be joined by Prop Holliday, a Pickswise player prop expert, to look at Week 2 injury news, line movements, their favorite teasers, underdog bets to make, and their Plays of the Day.

You can also access the show at any time through Spotify and Apple Podcasts (search for Let’s Bet It Presented By Pickswise).

The Week 2 edition of Pickwise Playbook, our weekly NFL preview show, is also available, featuring former NFL star Tank Williams, so be sure to check that out too!


The one-stop-shop for all our picks for today’s NFL action can be accessed via the hub of our NFL Week 2 betting guide, which has links to all our expert analysis, picks, parlays and prop bets.

Don’t forget to download our awesome Pickswise NFL Preview 2022, presented by Superbook Sports — you can read more about all the great NFL analysis inside it here.

There’s also a ton more NFL content to read such as our experts giving their NFL Week 2 best bets, our millionaire-maker parlay, and the weather report for every game in NFL Week 2.

The PLL championship game is on this afternoon so here’s how to watch the championship game, our experts best bets for the contest, and the best player prop bets to make for the big game.

Read all our great sports analysis as it arrives throughout the day on the Analysis tab.

Stat of the Day

Teams coming off a blowout in Week 1 (defined by a win of 21 points or more) are just 2-9 ATS in Week 2 since 2017.

Pickswise is the home of free NFL Picks and NFL Odds. Check out the latest NFL Prop Bets and NFL Parlays as well as expert NFL Underdog Picks and NFL Computer Picks.

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