NFL betting guide: Expert 2022 Week 2 NFL picks, predictions, odds & best bets
Welcome to the Pickswise NFL Week 2 betting guide. The nation’s favorite sport gave us a real treat in Week 1 with several wild finishes, and Week 2 also started with a bang as the Chiefs beat the Chargers on Thursday Night Football.
Week 2 promises more great entertainment with some interesting divisional matchups such as Buccaneers vs Saints, Colts vs Jaguars, Seahawks vs 49ers and Bears vs Packers.
Our experts have done the hard work so you have everything you need to bet better and get the right results. This is your one-stop shop for everything you need to make the most of your NFL Sunday — and the two Monday night games, as well!
Don’t forget to check out our great new game previews, which now include prop picks, projections, trends and same game parlays!
We had an amazing Week 1 of NFL handicapping, which you can read about here, and all our expert predictions for Week 2 can be found below.
NFL Week 2 picks
- NFL picks against the spread and total for EVERY Week 2 game
- NFL best bets
- NFL parlays
NFL Week 2 expert betting picks and predictions
- Jared Smith’s Week 2 best bets
- NFL Week 2 mega parlay (+1083 odds!)
- The Dog House: NFL best underdog bets
- Our NFL experts’ best bets
- Millionaire maker 14-team parlay
NFL Week 2 prop bets
- Week 2 anytime touchdown scorer picks
- Sunday 1:00 pm game player props
- Sunday 4.25 pm game player props
- Monday Night Football Titans vs Bills props
- Monday Night Football Vikings vs Eagles props
- ThriveFantasy NFL player props
NFL weather report
NFL Week 2 big-game predictions
- Colts vs Jaguars predictions
- Dolphins vs Ravens predictions
- Buccaneers vs Saints predictions
- Seahawks vs 49ers predictions
- Cardinals vs Raiders predictions
- Bears vs Packers predictions
- Titans vs Bills predictions
- Vikings vs Eagles predictions
Watch Pickswise Playbook!
Our weekly NFL show Pickswise Playbook, presented by Superbook Sports, is hosted by Lauren Jbara and Jared Smith and features former NFL player Tank Williams as this week’s guest.
Pickswise is the home of free NFL Picks and NFL Odds. Check out the latest NFL Prop Bets and NFL Parlays as well as expert NFL Underdog Picks and NFL Computer Picks.
