NFL betting guide: Expert 2022 Week 2 NFL picks, predictions, odds & best bets

Buffalo Bills quarterback Josh Allen (17) runs the ball during the second half in a AFC Divisional playoff football game against the Kansas City Chiefs at GEHA Field at Arrowhead Stadium.
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Phil Agius

NFL

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I've been writing about the NFL and a host of other sports for the UK's top daily betting paper the Racing Post for more than 20 years. An incurable Browns fan (1-31 survivor), I also specialise in all kinds of motorsport betting including F1, MotoGP, IndyCar and NASCAR. For Phil Agius media enquiries, please email contact@pickswise.com.
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Welcome to the Pickswise NFL Week 2 betting guide. The nation’s favorite sport gave us a real treat in Week 1 with several wild finishes, and Week 2 also started with a bang as the Chiefs beat the Chargers on Thursday Night Football.

Week 2 promises more great entertainment with some interesting divisional matchups such as Buccaneers vs Saints, Colts vs Jaguars, Seahawks vs 49ers and Bears vs Packers.

Our experts have done the hard work so you have everything you need to bet better and get the right results. This is your one-stop shop for everything you need to make the most of your NFL Sunday — and the two Monday night games, as well!

Don’t forget to check out our great new game previews, which now include prop picks, projections, trends and same game parlays!

We had an amazing Week 1 of NFL handicapping, which you can read about here, and all our expert predictions for Week 2 can be found below.

NFL Week 2 picks

NFL Week 2 expert betting picks and predictions

NFL Week 2 prop bets

NFL weather report

NFL Week 2 big-game predictions

Watch Pickswise Playbook!

Our weekly NFL show Pickswise Playbook, presented by Superbook Sports, is hosted by Lauren Jbara and Jared Smith and features former NFL player Tank Williams as this week’s guest.

Pickswise is the home of free NFL Picks and NFL Odds. Check out the latest NFL Prop Bets and NFL Parlays as well as expert NFL Underdog Picks and NFL Computer Picks.

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