NFL Week 6 Opening Lines, Odds & Best Bets: Cowboys woes likely to continue at Packers
On the heels of a wild Week 5 in which a whole host of games went down to the wire (including three overtimes and one tie), Week 6 of the 2026 NFL regular season is on the immediate horizon. It kicks off with Thursday Night Football between the Seahawks and Broncos, while the other primetime matchups are Cowboys vs Packers and Commanders vs 49ers.
Make sure you check out our NFL predictions as we add our picks on the side and total for every game throughout the week – and throughout the entire season. Also don't miss our NFL best bets for our 5-star plays, with our experts boasting a 13-8 record with Chris Farley on a 6-0 run! But for now, let's break down the NFL Week 6 opening lines and give our best early bet to make.
NFL Week 6 Opening Lines and Odds
Odds available at DraftKings Sportsbook at time of publishing
- Seattle Seahawks -3 (-102) vs Denver Broncos +3 (-118) - Thursday Night Football
- Houston Texans +3 (-120) vs Jacksonville Jaguars -3 (+100) - London
- New York Jets +7.5 (-110) vs New England Patriots -7.5 (-105)
- Baltimore Ravens -4.5 (-105) vs Cleveland Browns +4.5 (-115)
- Carolina Panthers +1.5 (-115) vs Philadelphia Eagles -1.5 (-105)
- Tennessee Titans +7 (-112) vs Indianapolis Colts -7 (-108)
- Pittsburgh Steelers -3 (-102) vs Tampa Bay Buccaneers +3 (-118)
- Chicago Bears -3 (-120) vs Atlanta Falcons +3 (+100)
- New Orleans Saints +1.5 (-120) vs New York Giants -1.5 (+100)
- Arizona Cardinals +12.5 (-108) vs Los Angeles Rams -12.5 (-112)
- Los Angeles Chargers +8.5 (-110) vs Kansas City Chiefs -8.5 (-105)
- Buffalo Bills -5.5 (-112) vs Las Vegas Raiders +5.5 (-108)
- Dallas Cowboys +1.5 (-118) vs Green Bay Packers -1.5 (-102) - Sunday Night Football
- Washington Commanders +7.5 (-112) vs San Francisco 49ers -7.5 (-108) - Monday Night Football
NFL Week 6 Early Best Bet: Green Bay Packers -1.5 over Dallas Cowboys (-102)
A heated rivalry game against the Bears may have been just what the doctor ordered to light a fire under the Packers. Head coach Matt LaFleur’s squad rolled to a 31-7 victory in Week 5. Now the question is whether Green Bay can sustain that same kind of intensity against an opponent outside of its own division. You have to think the Pack should be able to; after all, getting up for a showdown against the Cowboys can’t be too much to ask. Green Bay has certainly done it plenty of times in the past. In fact, the Packers are 10-1-1 SU in the last 12 head-to-head matchups, including 5-0-1 in the last six.
It is true that the Cowboys are playing on a long week, but the Packers are staying at home after hammering the Bears this past weekend. Rest really should not be much of an advantage for Dallas, which is coming off a disastrous home loss to a previously winless Tampa Bay team. The visitors have several guys – CeeDee Lamb, Tyler Guyton and Joey Porter Jr. to name a few – who are banged up, which could make what is already an uphill climb even more extreme.
We'll have NFL picks for every game in Week 6!
