Arizona Diamondbacks vs Chicago Cubs Prediction, Odds and Picks for Today, 05/01/26

Friday at 1:20 PM CT is the best time in baseball. It is matinee baseball at Wrigley Field, as the Arizona Diamondbacks take on the Chicago Cubs. The Cubs were off yesterday, and the D-Backs wish they were. Arizona was drubbed 13-1 by Milwaukee in an absolute disaster game. The only upside to that game for Arizona was that they basically gave the bullpen the day off. On Friday, we ask the most important question for a Wrigley game: what is the weather? It is going to be cold (40s) with the wind blowing in. That’s all I need to hear. Give me the game total under.

When it is cold and windy at Wrigley, I am pretty much an auto-under. The pitchers are Zac Gallen and Colin Rea. Gallen had to leave his last start early with an injury, but he did not end up missing any time. He has been good this season as he looks to rebuild from a bad 2025, and he is better than Rea. However, on cold days like this, it is just tough to pitch. It is even harder to hit, especially with the wind blowing in. I’ll be betting on the weather on Friday. The total sits at 7, and I don’t really want to chase it much lower, but runs should be at a premium.

Diamondbacks vs Cubs prediction: Under 7 (-110) available at the time of publishing. Playable to that number.

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