Chicago White Sox vs Arizona Diamondbacks Prediction, Odds and Picks for Today, 04/21/26

The Chicago White Sox are in Phoenix to take on the Arizona Diamondbacks in a 3-game series beginning on Tuesday night. The White Sox are coming off a series win on the road in Sacramento, but they are still just 5-8 on the road this season. Furthermore, Chicago’s team batting average of .206 on the road ranks 27th in baseball so far this season. Strangely enough, Chicago is tied for 3rd with 18 home runs on the road. Thus, the White Sox are extremely reliant on the long ball away from the Windy City and can be a bit boom-or-bust offensively on the road. That makes them tough to trust in this matchup.

Merrill Kelly is set to take the mound for the D-Backs. The 37-year-old right-hander began the season on the IL but made his season debut last week against the Orioles on Tuesday. He pitched well, allowing 5 hits and 2 earned runs over 5.1 innings in a 4-3 Arizona win. He did issue more walks (4) than strikeouts (3) — but now that he’s had a chance to get his feet wet, he should be able to work out the kinks in his second start of the season in this one. I expect him to be much more accurate in this outing against a weak Chicago lineup. Take confidence backing Arizona at home.

White Sox vs Diamondbacks prediction: Arizona ML (-150) available at time of publishing. Playable to -160.

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