Chicago White Sox vs San Diego Padres Prediction, Odds and Picks for Today, 05/03/26

The Chicago White Sox are trending in the right direction as an organization. They have won 5 straight and 10 of their last 14 games played to get within 1 game of .500. Sunday, they send Anthony Kay to the mound for his 7th appearance of the season. Kay has not been the best member of their starting rotation, posting a 6.12 ERA through 25 innings of work. The southpaw has a poor batted ball profile while failing to record whiffs and issuing out free passes. His 6.31 FIP and 8.19 xERA are somehow worse than his actual ERA, and the Padres offense should produce in this spot despite struggling against southpaw pitching.

Griffin Canning is set to make his season and Padre debut. Canning made 16 starts for the Mets in 2025, posting a 3.77 ERA across 76.1 innings pitched. He began this season in AAA for San Diego, and despite a 3.60 ERA there are some worrisome marks. Canning walked 12 batters and allowed 13 hits in those 15 innings of work, allowing 6 earned runs but also seeing 5 unearned runs cross the plate. He generated ground balls in 2025, but the rest of his batted ball profile was iffy. I look for runs from both sides on Sunday.

Chicago White Sox vs San Diego Padres prediction: Over 8.5 (-102) available at time of publishing. Playable to -105 odds.