Los Angeles Dodgers vs San Francisco Giants Prediction, Odds and Picks for Today, 04/23/26

The San Francisco Giants got off to a slow start this season, but they’ve turned things around, winning 5 of their last 6 games and putting themselves in a position to sweep the Los Angeles Dodgers. San Francisco got a dominant outing from Tyler Mahle last night, pitching 7 scoreless innings and giving up just 4 hits to pick up his first win of the season. Now, the Giants will turn to their ace Logan Webb, who enters at 2-2 with a 5.10 ERA and is still looking to find consistency early in the season. For the Dodgers, Tyler Glasnow has been sharp to start the year, going 2-0 with a 3.24 ERA and racking up 29 strikeouts across 25 innings pitched. 

While Glasnow has been dominant, this Giants lineup doesn’t go down easily – it ranks among the lowest strikeout teams in the league, which could limit Glasnow’s upside. Offensively, both teams have been comparable over their last 10 games, with the Giants hitting .263 and the Dodgers close behind at .258, but the Dodgers are holding a slight edge in runs scored — sitting at 4.5 runs per game in that span compared to the Giants’ 3.4. Even though the Dodgers have struggled offensively in this series, combining for a total of 7 hits, I think this is a game  in which they’ll bounce back.

The Dodgers are incredibly talented offensively, and for them to stay this cold for this long is unlikely. Plus, Webb has struggled in the majority of his starts this year. While San Francisco is playing better baseball as of late, you can’t count out the defending champs, and I think Glasnow and their offense will do just enough to pick up the win and end this brutal road trip for Los Angeles. 

Dodgers vs Giants prediction: LA Dodgers ML (-160) available at time of publishing. Playable at that number.

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