Milwaukee Brewers vs Detroit Tigers Prediction, Odds and Picks for Today, 04/22/26

The Detroit Tigers are looking to bounce back from a lop-sided 12-4 loss to the Milwaukee Brewers in the 2nd game of this mid-week series. Despite the ugly loss on Tuesday, the Tigers are the team to trust in Wednesday’s matchup. Detroit is loving life at home in the early going this season, as they are a solid 8-2 playing in front of their home fans at Comerica Park. The Tigers should also have confidence sending Casey Mize to the mound, as he has looked sharp in his first 4 starts of the season. The former No. 1 overall pick has issued just a single earned run over his last 2 starts and 12.1 innings of work, and he’s been extremely accurate with just 2 walks in that span.

The Brewers have been a little boom-or-bust so far this season. They raced out to an 8-2 start, but then endured a 6-game losing streak in mid-April. They then bounced back to win 4 in a row and Tuesday’s victory in Detroit gives them 5 wins in their last 6 games. But that inconsistency makes them hard to trust on a night-in and night-out basis right now. Playing at home, the Tigers are the team to back on the moneyline in this interleague matchup.

Brewers vs Tigers prediction: Tigers ML (-135) available at time of publishing. Playable at that number.