Milwaukee Brewers vs Detroit Tigers Prediction, Odds and Picks for Today, 04/22/26

The Detroit Tigers are looking to bounce back from a lop-sided 12-4 loss to the Milwaukee Brewers in the second game of this mid-week series. Despite the ugly loss on Tuesday, the Tigers are the team to trust in Wednesday’s matchup. Detroit is loving life at home in the early going this season, as it is a solid 8-2 playing in front of the home fans at Comerica Park. The Tigers should also have confidence sending Casey Mize to the mound, as he has looked sharp in his first 4 starts of the season. The former #1 overall pick has issued just a single earned run over his last 2 starts and 12.1 innings of work, and he’s been extremely accurate with just 2 walks in that span.

The Brewers have been a little boom-or-bust so far this season. They raced out to an 8-2 start, but then endured a 6-game losing streak in mid-April. The Brew Crew then bounced back to win 4 in a row and Tuesday’s victory in Detroit gives them 5 wins in their last 6 games. But that inconsistency makes them hard to trust on a night-in and night-out basis right now. Playing at home, the Tigers are the team to back on the money line in this interleague matchup.

Brewers vs Tigers prediction: Detroit ML (-135) available at time of publishing. Playable at that price.

Bet like a Caesar with this AMAZING new customer offer from Caesars Sportsbook, where you can receive DOUBLE YOUR WINNINGS on 10 straight wagers after making your first $1 bet! Become a Caesars member 👥 using the Caesars promo code PWCONTENT250BM, where you can bet on our Brewers vs Tigers picks.