Minnesota Twins vs New York Mets Prediction, Odds and Picks for Today, 04/22/26

From a 7-4 record to now a 7-16 overall record, all eyes are on New York as the Mets look to end a league-high 12-game losing streak. With MLB debutant Connor Prielipp set to make his first-ever start on the mound for Minnesota, this is an interesting spot for both sides. On one end, it’s an ideal spot for Prielipp to get going against a struggling lineup. But on the other end, this could be the ideal spot for New York to get back on track. Prielipp is highly touted as a prospect but has never thrown more than 77 pitches in a Triple-A start and likely won’t have a long leash in his debut. In relief, the Minnesota bullpen ranks 23rd in MLB with a 4.82 combined ERA. 

Clay Holmes (1.96 ERA, 1.06 WHIP) gets the start for New York. He is a righty who has arguably been New York’s most consistent starter thus far in 2026. Holmes falls in the 83rd percentile for pitching run value and has surrendered only 3 earned runs in his last 17.1 innings of work. The offensive numbers aren’t great for either side in this matchup, but I’ll lean on the presence of Holmes on the mound and take New York to be leading this game after 5 innings.

Twins vs Mets prediction: New York F5 -0.5 (-110) available at time of publishing. Playable at that number.

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