New York Yankees vs Houston Astros Prediction, Odds and Picks for Today, 04/24/26

The New York Yankees and Houston Astros are 2 teams going in opposite directions early on in the 2026 MLB season. The Yankees enter Friday night’s matchup with an overall record of 16-9, and they are currently riding a 6-game winning streak. On the other side, the Astros are 10-16 overall and have dropped 5 of their last 7 games. Things won’t get any easier for Houston on Friday when they send Lance McCullers Jr. to the mound.

McCullers posted a 6.51 ERA across16 games and 55.1 innings last season, and he is off to a rough start this season. The 32-year-old right-hander owns a less-then-stellar 6.20 ERA through 4 starts and 20.1 innings of work. The Astros have lost 3 of his 4 starts, and going up against New York presents a tough challenge. New York starting pitcher Will Warren has been impressive early on in 2026, as he’s allowed 2 runs or fewer in all 4 of his starts and is holding his opponents to a .210 batting average. He racked up 11 strikeouts with no walks against the Royals in his last outing, and he should be able to keep the momentum going in this one. Fade the Astros and back the Yankees on the moneyline.

Yankees vs Astros prediction: Yankees ML (-150) available at time of publishing. Playable to -155.