San Diego Padres vs San Francisco Giants Prediction, Odds and Picks for Today, 05/04/26

The San Diego Padres and San Francisco Giants kick off a three-game series at Oracle Park between these National League West Division rivals. The Padres turn to RHP Randy Vasquez, who has posted a 3-0 record, 2.94 ERA and 1.16 WHIP across six starts in 33 2/3 IP. That includes a victory last time out against the Colorado Rockies in his most recent road start on April 21. The Padres have posted a perfect 6-0 record in six starts with Vasquez on the hill, while going 14-13 in each of their other games. The Padres offense really struggled over the weekend against the lowly Chicago White Sox, winning just one of three games, with a total of six runs. They’re 1-4 in the past five games, too.

For the Giants, believe it or not, they’re actually much worse offensively. They enter play with a six-game losing streak, and they cobbled together just two total runs of offense in an interleague road sweep at the hands of the Tampa Bay Rays, getting outscored 10-2. In the six-game skid, San Francisco has managed just nine total runs, or 1.5 runs per game (RPG). Look for the Giants to really struggle against Vasquez, who is cooking right along.

Padres ML (-150) at time of publishing. Playable to -160.