San Diego Padres vs San Francisco Giants Prediction, Odds and Picks for Today, 05/04/26

The San Diego Padres and San Francisco Giants kick off a 3-game series at Oracle Park between these National League West Division rivals. The Padres turn to RHP Randy Vasquez, who has posted a 3-0 record, 2.94 ERA and 1.16 WHIP across 6 starts in 33.2 innings. That includes a victory last time out against the Colorado Rockies in his most recent road start on April 21. The Padres have posted a perfect 6-0 record in 6 games with Vasquez on the hill, while going 14-13 in each of their other games. The Padres’ offense really struggled over the weekend against the lowly Chicago White Sox, winning just one of 3 games with a total of 6 runs scored. They are 1-4 in the past 5 contests, too.

The Giants, believe it or not, are actually much worse offensively. They enter with a 6-game losing streak, and they cobbled together just2 total runs of offense in an interleague road sweep at the hands of the Tampa Bay Rays — getting outscored 10-2. In the 6-game skid, San Francisco has managed just 9 total runs — or 1.5 runs per game. Look for the Giants to really struggle against Vasquez, who is cooking right along.

Padres vs Giants prediction: San Diego ML (-150) available at time of publishing. Playable to -160.

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