St. Louis Cardinals vs San Diego Padres Prediction, Odds and Picks for Today, 05/07/26

The St. Louis Cardinals and San Diego Padres open a 4-game series at Petco Park in Southern California. The Cardinals limp in with just a single win in the past 3 games, but they’re coming off a 4-game sweep of the Pittsburgh Pirates in their most recent road series from April 27-30, while going 10-2 across the previous 12 games away from home. Cardinals LHP Matthew Liberatore is on the hill, and he is 1-1 with a 4.50 ERA and 1.50 WHIP this season. On the road, he doesn’t have a record, while posting a 4.09 ERA in 11 IP with two homers allowed and a .286 batting average against.

The Padres turn to RHP Michael King, who has been tremendous this season. He is just 3-2, but he has a 2.95 ERA and 1.13 WHIP across 7 starts and 39.2 IP, including 3 quality starts in his past 5 outings. He hasn’t allowed a home run in 4 of his past 5 appearances, too. San Diego is 3-1 in the past 4 games, although it did lose 4-0 last time King worked at home against the Chicago White Sox on Saturday. Still, the Padres should be trusted at home against the Cardinals in what could be a lower-scoring game.

Cardinals vs Padres prediction: Padres ML (-165) available at time of publishing. Playable to -170.

Skip the waitlist and sign up for Polymarket RIGHT NOW to get instant access and a $20 trading bonus! You can join Polymarket by clicking here and trade on our Cardinals vs Padres predictions.