The Athletics vs Seattle Mariners Prediction, Odds and Picks for Today, 04/22/26

Despite leading the division and winning the first two games of this series, the Athletics are massive underdogs to the Seattle Mariners on Wednesday afternoon. It could be a failure to believe in the team that is perpetually a bottom-feeder in the American League West and punching up at the Mariners, who often sit near the top of the division, but it might be time to start realizing that the Athletics are for real with their blend of young speed, defense, and bats.

With all that being said, the Mariners aren’t going to go down easy and let the Athletics sweep them at T-Mobile Park. Logan Gilbert has been coming into his own for Seattle recently, and Aaron Civale had some regression to the mean in his last start after being a solid option early in the season.

After a rough first two starts in March, Gilbert has gone 18.1 innings in April, allowing just five earned runs. He got into some trouble with home runs over his past two starts, but he matches up well against the Athletics. His swing-and-miss stuff has also been electric recently, striking out seven batters in each of his past two games.

Civale followed up two great starts against the New York teams by allowing 11 hits and five earned runs against the Chicago White Sox in his most recent start. Chicago’s hitters finally started barreling up the righty who was getting a bit lucky with the hard contact he was giving up all season, and that could continue against Seattle today.

Athletics vs Mariners prediction: Mariners -1.5 (+115) available at time of publishing. Playable at that number.