Toronto Blue Jays vs Los Angeles Angels Prediction, Odds and Picks for Today, 04/22/26

The Toronto Blue Jays are starting to roll after a bit of a World Series runner-up hangover to start the season. Injuries to the starting rotation haven’t helped the Blue Jays, but a recent three-game winning streak has the team hopeful they can turn it around. It has been a bit of a different season for the Los Angeles Angels, as they started better than expected and had their fans thinking about a special season, but have fallen back recently with four consecutive losses.

The good news for the Angels is that they have the upper hand in the pitching matchup tonight. The Blue Jays send Eric Lauer to the mound, who was projected to start the season in the bullpen, but the team had to insert him back into the rotation with all their injuries. Lauer’s performance this season has shown why the team didn’t have confidence in him to stay in the rotation, as he has a 7.13 ERA and 12 earned runs over his last 12.1 innings.

Jose Soriano has been lights out this season, which is going to be scary for a Blue Jays team that has been struggling offensively at times. Soriano has won all five starts this season, owning an incredible 0.28 ERA. He has allowed zero earned runs over his last 12.2 innings, which is a shocking contrast to Lauer’s performance over the same time frame.

After dropping the first two games of the series to the Blue Jays, the Angels could find a way to give them one back in this game.

Blue Jays vs Angels prediction: Angels ML (-160) available at time of publishing. Playable at that number.