NFL Best Bets

Get our experts’ best NFL bets this week and every week of the 2025/26 season. Our experts analyze their NFL picks and predictions across a whole host of markets to find you their best NFL Bets today.

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9:30 AM ET
Tomorrow
Los Angeles Rams
Jacksonville Jaguars
Rams
Jaguars
Point Spread PickBest Bet
JAX Jaguars +3.0(-110)

The next London game on the NFL slate is this Week 7 matchup between the Los Angeles Rams and Jacksonville Jaguars in a battle of 4-2 teams. Jacksonville was riding high off its signature primetime win over the Chiefs, and then came crashing back down to earth last week in a loss to the Seahawks. While I don’t think the Jags were ever as good as their 4-1 record suggested, I also don’t think the Rams deserve to be 3-point favorites here.

The Jaguars’ loss to Seattle has more to do with the Seahawks just being a legitimately-good team than anything else, and I’m not overreacting after 1 week just like I wasn’t overreacting after their win over Kansas City. Liam Coen has something cooking, and the ground game is back with Travis Etienne averaging 5.3 yards per carry. I haven’t been all too impressed by the Rams even though Matthew Stafford has played at a high level, and I’m not giving them much credit at all for beating a Cooper Rush-led Ravens team last week.

Just the week before, the Rams lost to Mac Jones at home. Los Angeles’ 4 wins this season have come against a Texans team that started the year terribly, an awful Titans team, the Colts in a fluky game where Indy blew the game by dropping the ball at the goal line, and then Rush last week. The Jaguars have played in London a ton in recent years and they played there twice last year, so they won’t have to make nearly as much of an adjustment as the Rams and should acclimate better. Give me the underdog in this spot.

Rams vs Jaguars best bets: Jacksonville Jaguars +3 available at time of publishing. Playable to 1.5.

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Andrew Ortenberg
1:00 PM ET
Tomorrow
Carolina Panthers
New York Jets
Panthers
Jets
Game Totals PickBest Bet
Under 42.5(-110)

Just how bad is the Jets’ passing attack? Their 144.2 yards per game are 6.3 fewer than the pathetic Titans and at least 24.3 fewer than every other team in the NFL. What’s amazing is that New York is this bad even though Justin Fields has not thrown a single interception yet this season. Just think how hopeless the offense will be once Fields starts forcing things and getting picked off! The Jets’ only real hope is to keep the football on the ground, but the Panthers rank #9 league-wide against the run, surrendering just 94.5 yards per contest on 4.1 yards per carry. That is part of the reason why my Jets vs Panthers prediction is under 42.5.

Adding insult to injury, or vice versa, New York wide receiver Garrett Wilson is doubtful for Sunday due to a knee problem. WR2 Josh Reynolds (hip) did not practice on Wednesday and is questionable. There is no reason to think that things will suddenly improve for Fields when he could be without 2 of his primary pass-catching targets. Fortunately for the Jets, they can at least play some semblance of defense thanks to CB Sauce Gardner and DT Quinnen Williams. Meanwhile, the Panthers have 3 offensive starters listed as questionable: RB Chuba Hubbard, TE Ja’Tavion Sanders and OT Taylor Moton. Since Young is inconsistent and Hubbard (who might not even play) has done nothing on the ground so far in 2025, Carolina does not inspire much confidence on offense. I’m backing the under with confidence.

Panthers vs Jets prediction: Under 42.5 (-108) available at time of publishing. Playable to 41.

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Ricky Dimon
1:00 PM ET
Tomorrow
New England Patriots
Tennessee Titans
Patriots
Titans
Point Spread PickBest Bet
NE Patriots -7.0(-110)

The New England Patriots surprisingly find themselves atop the AFC East heading into Week 7 of the NFL season. They are 4-2 and own the head-to-head tiebreaker over the Bills, having taken down Josh Allen and company in Buffalo earlier this month. New England now faces arguably the worst team in football, the Tennessee Titans, on Sunday afternoon. This is a tale of 2 franchises going in opposite directions — and with the spread set at no more than a touchdown, my Patriots vs Titans pick is for the visitors to win and cover. Tennessee just fired head coach Bill Callahan and for good reason. The Titans 1-5 and their only win is a miracle (“fluke” would probably be an even more accurate description) fourth-quarter comeback from 15 points down against the Cardinals, made possible by Arizona RB Emari Demarcado dropping the ball before going into the endzone followed by one of the luckiest touchdowns in football history after Arizona fumbled an interception. 

Teams can sometimes galvanize around an interim head coach, but that’s usually when they have a chance to really turn around the season. That obviously isn’t the case with Tennessee. The Titans know as well as everyone else that this is a rebuilding process that will require multiple years. Now they are being asked to compete with a team is on a 3-game winning streak and has lost just once since Week 1 in a 1-possession game against the 4-1 Steelers? Drake Maye looks like the real deal at quarterback and New England is 3-0 on the road. It’s not like the Titans have any kind of significant home-field advantage, either, so the Patriots should be even bigger favorites and can be expected to win by more than a touchdown. 

Patriots vs Titans prediction: New England Patriots -7 (-110) available at time of publishing. Playable at that number.

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Ricky Dimon
1:00 PM ET
Tomorrow
New Orleans Saints
Chicago Bears
Saints
Bears
Point Spread PickBest Bet
NO Saints Win +4.5(-110)

Two quarterbacks from the 2024 NFL Draft class will face off here as Spencer Rattler and the New Orleans Saints get ready to take on Caleb Williams and the Chicago Bears. Chicago is coming off their best win of the season after beating Washington on Monday Night Football, and I think now is the time to sell high. Sure the Bears are on a three-game win streak, but that’s highly misleading.

To start this win streak off they beat a mediocre Cowboys team that just lost to the Panthers, and the next two wins were by just a single point each against the Raiders and Commanders. Right before that, they got demolished while giving up 51 points to the Lions, so let’s not get carried away with Bears excitement. They trailed most of the game against a really bad Raiders team, and I don’t see any reason for them to be such a large favorite here against the Saints who aren’t completely helpless. New Orleans just played a pretty tight game against the Patriots where Rattler averaged 8.7 yards per attempt with no turnovers against a good New England D, and the week before that they beat a suddenly resurgent Giants team by double digits.

Rattler has quietly been having a pretty solid season, and most importantly has been taking care of the ball, with only 1 interception through 6 games. The Saints are better than their record indicates, and they had a really difficult schedule to open the season. Alvin Kamara just got in a full practice on Friday for the first time in two weeks, so it seems like he is thankfully pretty much back to full health which will be a big boost to the offense.

Saints +4.5 at publishing.

Andrew Ortenberg
4:25 PM ET
Tomorrow
Washington Commanders
Dallas Cowboys
Commanders
Cowboys
Point Spread PickBest Bet
WAS Commanders -1.5(-110)

These two teams sit right behind the Eagles for first place in the NFC East as Washington (3-3) heads to Dallas (2-3-1) on late Sunday afternoon. Both squads are coming off losses last week in heartbreaking fashion. The Commanders rallied from a 13-0 deficit to lead the Bears on Monday night, 24-16 in the fourth quarter. Chicago scored the final 10 points of the game, capped off by a game-winning field goal in the final seconds for a 25-24 triumph. Meanwhile, Dallas went back and forth with Carolina on the road before allowing the go-ahead field goal as time expired in a 30-27 defeat to the Panthers. It marked the fourth time in the last five games that the Cowboys yielded at least 30 points, while being the only team in the league to give up an average of over 400 yards a game.

Commanders’ QB Jayden Daniels has thrown four touchdown passes in the past two games after returning from a knee injury. In each of his last three starts, Washington has trailed by double-digits before scoring their first points. Dallas has played probably the two of the most exciting games of the season at AT&T Stadium. The Cowboys outlasted the Giants in overtime in Week 2, 40-37 and rallied to tie the Packers, 40-40 in Week 4. The offense has been great, but they will get back one of its top weapons in WR Ceedee Lamb, who is expected to return following a four-game absence with an ankle injury.

Last season, the road team won each matchup as Dallas held off Washington, 34-26 in D.C., while the Commanders rallied late against the Cowboys in Arlington, 23-19. In both games, the Cowboys played without QB Dak Prescott, who was sidelined for the season halfway through. Prescott threw four TD passes in each of the two wins over Washington during the 2023 season, but the Commanders finished 4-13 before drafting Daniels the following spring. Dallas is 6-2 against the spread in its last eight opportunities as an underdog since last November. However, seven of those covers came as a ‘dog of at least four points. In this spot, let’s back Washington as a short favorite to grab the road victory.

Washington Commanders vs Dallas Cowboys best bet: Commanders -1.5 (-110) available at time of publishing. Playable to -2.5.

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Kevin Rogers
8:20 PM ET
Tomorrow
Atlanta Falcons
San Francisco 49ers
Falcons
49ers
Point Spread PickBest Bet
SF 49ers -2.0(-110)

This is the definition of a regression game on both sides. We’ll start with the 49ers. San Francisco will be coming off a tough loss at Tampa in Week 6 but they have plenty to hang their hats on. Veteran all-pro linebacker Fred Warner sustained an injury early in the game and Mac Jones threw 2 interceptions, but the visitors were still in a one score game entering the fourth quarter. The Bucs did a nice job closing it out late, but it was largely an even matchup. For example, San Francisco gained 363 yards while Tampa gained 352. Despite their many injuries on both sides of the ball, the 49ers went toe-to-toe in enemy territory with one of the best teams in the NFL. I left feeling better about their potential this season, regardless of the dwindling health of their roster.

This Sunday sets up beautifully for a redemption spot. Early in the week, reports out of the 49ers camp suggest that George Kittle, Brock Purdy and Ricky Pearsall are all trending toward playing on Sunday night. Kittle has the most challenging journey to return, since his 12 day practice window just opened following 4 weeks on the injured reserve. Heading back home following a disappointing loss, San Francisco will take any healthy returning player that they can get.

The Falcons did nothing but impress in their Week 6 victory over the Bills on Monday Night Football, but there is also some reason to believe it was fluky. Firstly, the game started on a Bijan Robinson fumble and Bills’ recovery, but Buffalo was offside and it negated the turnover. The Bills also have serious issues with their run-defense, so predictably they were overwhelmed by Robinson and Tyler Allgeier — arguably the best rushing-duo in the NFL. The 49ers don’t have the same issues, ranking 12th in yards per carry allowed. Atlanta mostly won via big plays in their ground attack, with Robinson and Allgeier galloping down the sidelines on seemingly every possession. We doubt their offense can be that simple and still experience the same success against an above-average defensive coordinator in Robert Saleh. This fits a pattern we love; an overconfident team on the road following a strange win against a home team getting healthier and historically more buttoned up than the opponent. The value is clear.

Atlanta Falcons vs San Francisco 49ers prediction: 49ers -2 (-110) available at time of publishing. Playable to -2.5.

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Chris R. Farley
7:00 PM ET
Mon Oct 20
Tampa Bay Buccaneers
Detroit Lions
Buccaneers
Lions
Game Totals PickBest Bet
Over 52.5(-110)

The Lions are already in a vulnerable position on defense, without Terrion Arnold and damaged depth in their cornerback and safety rooms. It’s even more dire now that Brian Branch, who lost his cool and started a fight after their loss at Kansas City last week, is now suspended for one game. Baker Mayfield and the Tampa Bay offense doesn’t need any help getting off the ground, ranked in the top-10 in nearly every offensive category, including a sixth best 27.5 points per game. In a dome against banged up Lions defense, we have little doubt that the Bucs can bring plenty of points to Ford Field.

Of course, on the other side we feel the same way. The Lions and Bucs can both get to the quarterback, both ranked in the top-12 in that category, but that’s about the only factor that concerns us for each offense. Of course, Tampa’s run defense is very formidable, but at home the Lions have run for 286 yards in two games behind one of the best running back tandems in the NFL. Considering the fact that Detroit was held to just 17 points on the road last weekend, a long week of preparation sets up for a dominant performance from Jared Goff, Jahmyr Gibbs and company. We recognized that this total is sky high, but there’s simply no other way we can look.

Tampa Bay Buccaneers vs Detroit Lions prediction: Over 52.5 (-110) available at time of publishing. Playable to 53.5.

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Chris R. Farley
NFL Best Bets
50.0%
Win %
9Wins
9Losses
0Pushes
Percentage only includes Wins and Losses

At Pickswise our experts put in countless hours of research and analysis every week to bring you free NFL best bets. Although the NFL regular season is just 18 weeks long, there are still 272 regular-season NFL games to decipher, as well as the NFL playoffs, so we bring you free NFL best bets this week and across the whole season and post-season.

Best NFL Bets Today

The NFL action comes thick and fast during the season and we cover all of it. Our NFL Best Bets should be your first port of call here at Pickswise alongside the NFL Picks page where you can find the entire catalog of our weekly game previews which combine for a comprehensive view of all of today’s NFL games and best bets. Check back every week for those Monday Night, Thursday Night and Sunday slates’ best NFL picks, all for free. 

Best NFL Bets This Week

The NFL is very much a look-ahead sport, particularly within sports betting. Almost as soon as the previous week’s games are done, oddsmakers and bettors alike are already trying to find the best bets for NFL this week. Here at Pickswise, we’re no different.

You can often find great value early in the week and our experts will take an early look ahead, so we get our best bets for NFL this week posted on-site as soon as possible, so you can lock in those best lines and odds before the inevitable movement later in the week. Be sure to keep an eye on the NFL best bets page every day on game week as our experts continue to highlight those biggest edges and best NFL bets.

What Is An NFL Best Bet at Pickswise?

Our expert NFL cappers post their best bets on this week’s NFL games across a whole host of betting markets. Each of our selections on Pickswise is given a confidence rating ranging from 1 to 3 stars, with 3 stars being the most confident, and 1 the least. Our NFL Best Bets page details those 3 star rated bets, making them our expert’s NFL Best Bets on this week’s games.

How We Decide Our Best NFL Bets at Pickswise

Each week of the NFL season, as our experts deep-dive into the stats and make their picks and predictions for the week’s coming games each expert handicapper gives their reasoning and the data to back up their selections. Through a robust process of debate and consideration, taking into account the odds, potential winnings and an expert judgement on the bet’s outcome, they come to a consensus on the confidence rating for each play. Only those that get a 3 star confidence rating through this process qualify as an NFL best bet.

All our handicappers vie for their picks to get the NFL best bet stamp, each and every week of the season. It’s this friendly competition amongst experts that ensures are NFL best bets are indeed the best NFL bets you’ll find anywhere.

Where Should I Bet On Your NFL Best Bets Today

Another important strategy for maximizing your NFL betting success is to make sure you have access to the best odds and lines available across all of the best online sportsbooks.

Alongside our NFL best bets, we also highlight the best odds and lines that the sportsbooks are currently offering. This ensures you’re maximizing your chances of turning a profit over time as every half point or fractional odds difference adds up over the season.

For more on our recommended NFL sportsbooks, check out our rankings for the best NFL betting sites. The best odds, a diverse range of NFL betting markets and an overall user-friendly app experience are just some of the key factors we consider.

Unsure where is best to place your online sports wagers? Or looking to make the most of new player bonuses and promo codes? Be sure to check out our
Online Sportsbook Promotions for expert analysis of the best sportsbook welcome offers available in your state. 


57 Wins from 2024/25 NFL Best Bets

When Pickswise tells you that we have an NFL Best Bet, we mean it. In the 2024 season, our team of expert NFL handicappers finished with 57 wins on our NFL best bets and we are hungry to provide even more winners this season. We don’t just throw around 3 star plays, all of our cappers and editors meticulously break down each pick and predictions before we put our NFL best bet stamp on it. We often have best bets each week of the season, but tail our expert NFL cappers with confidence this week. 

Andrew Wilsher, Pickswise Managing Editor

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NFL Best Bets FAQs

There are endless ways in which you can bet on the NFL and the Best Bet is a winning one. The Pickswise Best Bets page is a collation of our expert handicappers’ most confident selections on this week’s NFL games. While we can’t guarantee every bet will win, we have a long-trusted and proven record, our NFL Best Bets returned 57 wins across the 2024/25 season.

The most important numbers to consider when betting on the NFL are 3 and 7. A lot of games in the NFL are decided by one score so when you’re looking at spread lines you must keep Field Goals and Touchdowns at the forefront of your mind, as there is a big difference between -3.5 and -2.5 and -6.5 and -7.5.

At Pickswise we use a star system to show our cappers’ confidence in that particular pick. All of our Best NFL Bets get our top confidence rating of 3 stars.

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