Pickswise
March Madness First Four Best Bets: Take the points with Pitt

March Madness First Four Best Bets: Take the points with Pitt

Pickswise_Test
Pickswise_TestAuthor
UpdatedSep 15, 2026
Reading time3 min

After a year of waiting, March Madness is finally back. It’s one of the most exciting and intense tournaments in the calendar year, and this year’s madness looks no different. Before we get into the round of 64, we have the First Four matchups. I have taken a look at the First Four matchups and have come up with 2 best bets to make. Also, be sure to check out all of our March Madness picks each game.

You can bet on these college basketball best bets with FanDuel Sportsbook, which has the best odds available and a great new customer offer where you can get 10x your first deposit in bonus bets! Click here to take advantage of this can’t-miss offer.

 

Pittsburgh +2 (-110) over Mississippi State

One of the First Four matchups pits Pittsburgh against Mississippi State. These teams play very different styles of basketball, as Pitt relies on its solid offense while MSU banks on its defense. Admittedly, the Mississippi State defense has been one of the better units in the nation this season. But that has changed recently, as the Bulldogs have given up 68 points or more in each of the last 4 games. Their offense has also been waking up at the end of the season, as they scored 68 points or more in 7 of the last 9 games — but that excellent shooting streak is bound to end soon.

As for the Panthers, they had an excellent season in the ACC. They finished 22-11 and were impressive in conference against some of the better teams in the country. Their offense should carry them through this matchup as they averaged nearly 76 points per game, which included shooting 36% from 3-point land. This game should be closer to a pick’em, so I’ll take the points with the Panthers.

Check out our Pittsburgh vs Mississippi State predictions

PointsBet is one of the fastest-growing sportsbooks in America, and with a sign-up offer for up to 5 different $50 bonus bets, it’s easy to understand why! Join PointsBet right now to earn some bonus bets.

 

Arizona State -2 (-110) over Nevada

It was an impressive Pac-12 Tournament showing from Arizona State, which heads into the First Four on a high note. The Sun Devils beat Oregon State to open the tournament and then knocked off USC before falling to in-state rival Arizona. Their offense was solid throughout the Pac-12 Tournament, as they average around 70 points per game — but it’s their defense that makes the difference in games. The Sun Devils limit opponents to just 39.4% from the floor, a truly exceptional rate. In fact, it was the 12th-best rate in the entire nation. Nevada had a solid season but did not get much experience against legitimate teams, and I think that will come back to bite the Wolf Pack. Arizona State showcased its abilities in the Pac-12 Tournament; I liked what I saw, and with such a small spread I’ll back the Sun Devils by a bucket.

SuperBook has set the standard in US sports betting since 1993 and new customers can join right now and get a sign-up bonus up to $250 when you use promo code “Pickswise”! Click here to join the #1 sportsbook in Vegas.

 

Pickswise is the home of free College Basketball Picks and College Basketball Predictions. With top College Basketball picks available daily, including our College Basketball Best Bets. 

Exclusive Offers
See all
Polymarket — Deposit $10, Get a $50 Trading Bonus
Polymarket
PolymarketDeposit $10, Get a $50 Trading Bonus
$50
Novig — Deposit $10, Get $25 in Trade Credits
Novig
NovigDeposit $10, Get $25 in Trade Credits
$25
Underdog — First-Time Deposit Match + Keep Your $1,000,000
Underdog
UnderdogFirst-Time Deposit Match + Keep Your $1,000,000
$1,000,000
Onyx Odds — Spend $10, Get $111 in Bonus Picks
Onyx Odds
Onyx OddsSpend $10, Get $111 in Bonus Picks
$111
Bet365 — Bet $10, Get $365 in Bonus Bets, Win or Lose
Bet365
Bet365Bet $10, Get $365 in Bonus Bets, Win or Lose
$365
Fanatics — Bet $20, Get $350 in FanCash
Fanatics
FanaticsBet $20, Get $350 in FanCash
$350
BetMGM — Get Up to $1500 in Bonus Bets if your First Bet Does Not Win
BetMGM
BetMGMGet Up to $1500 in Bonus Bets if your First Bet Does Not Win
$1,500
ProphetX — Trade $50, Get $75
ProphetX
ProphetXTrade $50, Get $75
$75
Rebet — Get a 100% Deposit Match up to $100
Rebet
RebetGet a 100% Deposit Match up to $100
$100
FanDuel — Bet $5, Get $350 in Bet Reset Tokens over 7 Days
FanDuel
FanDuelBet $5, Get $350 in Bet Reset Tokens over 7 Days
$350
When you click our links to visit an operator and sign up, we may receive a commission at no extra cost to you. This financial relationship helps support our site.
Pickswise
Get exclusive 
free sports picks
to your email
subscriber 1
subscriber 2
subscriber 3
18K users have
already subscribed
Enter your email address
By signing up you agree to our terms and privacy