Monday Night Football DFS/DraftKings lineup advice for Buffalo Bills vs. San Francisco 49ers

Nick Mullens of the San Francisco 49ers
Photo of Ricky Dimon

Ricky Dimon

NFL · 1 year ago

Show Bio

Since graduating from Davidson (The College That Stephen Curry Built), I have been writing about sports--just about any and all you can think of!--and coaching tennis in Atlanta, Ga. Beyond the four major sports, I am an avid tennis fan and cover the ATP Tour on a daily basis. If I'm not busy writing, you can generally find me on a tennis court or traveling the world wherever a sporting event takes me.

It will be a rare meeting between the Buffalo Bills and San Francisco 49ers when the Bills travel across the country (well, not the entire way) for this Monday Night Football showdown. It’s actually not taking place in San Francisco, because the 49ers are playing the rest of their “home” games at the Cardinals’ stadium in Glendale, Ariz. due to strict coronavirus protocols in California. That only adds to the bizarre nature of this 2020 NFL season—and to Week 13, itself. Monday Night Football actually isn’t the final game of the week; nor is it the only game on Monday. Buffalo-San Francisco will be preceded by Steelers vs. Football Team and it will be followed by Ravens vs. Cowboys on Tuesday.

Still, this is a stand-alone game in the primetime slot on Monday and therefore it deserves careful evaluation in daily fantasy. Here’s our six-man lineup.

Captain: Deebo Samuel, WR, 49ers ($8,800, or $13,200 as captain)

Samuel was out for more than a month because of a hamstring injury. No matter. He got right back in gear during San Francisco’s Week 12 upset of the Rams, catching 11 of his 13 targets for 133 yards. It doesn’t appear to matter which quarterback is throwing the football to Samuel. Nick Mullens hit the former South Carolina standout with pass after pass last weekend and Mullens will be back under center with Jimmy Garoppolo sidelined. This Buffalo defense has been struggling so the Mullens-Samuel connection should be line for another big day.

Deebo Samuel

Flex: Nick Mullens, QB, 49ers ($10,200)

As the above comments suggest, we are also rolling with Mullens. The third-year quarterback out of South Carolina already has six starts under his belt in 2020, so he should be getting more and more comfortable in the 49ers’ offense. Interceptions have been a problem, but Buffalo’s defense has come up with only eight picks so far this season. The Bills are ripe for the picking and Mullens is capable of capitalizing.

Flex: Raheem Mostert, RB, 49ers ($9,600)

Buffalo is even worse against the run than it is against the pass. This team is 25th in the NFL in rushing defense (129.6 yards per game allowed) and 27th in yards per rush attempt allowed (4.7). Even more alarming is that the Bills have surrendered 16 touchdowns on the ground, which was tied for third-most in the league going into Week 13. Like Samuel, Mostert returned for a month-long absence last week and he promptly found the endzone. He should be able to do the same against the Bills.

Flex: Brandon Aiyuk, WR, 49ers ($7,000)

We are staying on the 49ers’ bandwagon for this high-risk, high-reward pick. It’s only risky because Samuel is back and now Aiyuk is WR2 instead of WR1. When he was Mullens’ main weapon, the rookie out of Arizona State went on a three-game streak in which he combined for 21 receptions, 281 yards, and two touchdowns. Overall, he has scored three times in his last four appearances. Against Buffalo, there could be room for both Samuel and Aiyuk to have success.

Flex: Cole Beasley, WR, Bills ($6,800)

It’s not like this game is going to be all 49ers all the time, so we are also trying our hand with Beasley. The veteran receiver out of SMU is boom or bust, which is never a bad option in daily fantasy. You need to go big in order to win. Beasley disappears in some games, but twice this year he has made 11 catches for more than 100 yards. He has also scored three times. San Francisco has given up 17 touchdowns through the air compared to eight on the ground.

Flex: Richie James, WR, 49ers ($2,600)

With mere change left over, James is not a bad play. After all, this is a guy who once had nine receptions on 13 targets for 183 yards and one TD. Obviously his value is diminished with Samuel and Aiyuk ahead of him on the depth chart, but clearly the talent is there for another surprise performance.

Pickswise is the home of free NFL picks. Check out the latest NFL props and NFL parlays as well as expert underdog predictions and computer picks.

Virginia Bonuses

See All
FanDuel Sportsbook


Get a $1,000 Risk-Free Bet

Sign up for a new FanDuel Sportsbook account and make your first deposit of $10+

Place your first bet up to $1,000 risk-free!

Get refunded up if you lose up to $1,000

Must be 21+. First online real money wager only. $10 first deposit required. Bonus issued as non-withdrawable free bets that expire 14 days after receipt. See full terms at



Bet $5+ On Any NFL Pre-Game ML, Get $200 If Your Bet Wins

Sign up for a new account with DraftKings Sportsbook and make your first deposit

Bet $5+ on any NFL pre-game ML

Win $200 if your team wins

Offer valid for new players only. Must be 21 years or older to play. Reward paid in site credit. Full terms available at DraftKings Sportsbook.



Get a $100 Risk-Free Bet!

Register for a new Unibet account & make a deposit

Place your first bet up to $100 risk-free!

Get refunded up if you lose up to $100

New players only. Terms & conditions apply. 21+. VA only.



Get 4x $200 In Free Bets

Sign up for a new PointsBet account

Bet up to $200 and If you lose, you get a refund

You will receive Free Bet(s) in the amount of the losing wager(s), up to $200 each for four days.

Must be 21+. Full terms are available at PointsBet.

Caesars Sportsbook


Get a $1,250 risk-free bet

Sign up for a new Caesars Sportsbook account

Place your first bet of $10 or more

If your first bet loses, you’ll receive a refund up to $1,250 from Caesars in free bets

21+. Terms and conditions apply.



Get a $1,000 Risk Free Bet

Register for a new BetMGM & deposit

Place your first bet up to $1,000 risk-free!

Get refunded up if you lose up to $1,000

21+. Terms & conditions apply.



Get Your First Bet Risk-Free Up To $500

Sign up for a new BetRivers account using promo code PICKSWISE

Make your first deposit & get up to $500 in free bets

To get $500 in free bets, wager $500

Must be 21+. Play in IA Only. Gambling Problem? Call 1-800-BETS OFF



Bet $5+ on MLB and get $100 in Free Bets Instantly!

Sign up for a new account with DraftKings Sportsbook and make your first deposit

Bet $5+ on any MLB team to win their next game

Win $100 no matter what!

Offer valid for new players only. Must be 21 years or older to play. Reward paid in site credit. Full terms available at DraftKings Sportsbook.



Get 5x $100 in Free Bets With PointsBet's Second Chance

Sign up for a new PointsBet account

Make a bet of up to $100 and receive a refund if you lose

Get this offer once a day for the first 5 days you sign up

Must be 21+. Full terms are available at PointsBet.



Get a $1,000 Deposit Bonus!

Register for a new DraftKings Sportsbook account & deposit

DraftKings will match 20% of your deposit up to $1,000 total

To get a $100 bonus, deposit $500

21+. Terms & conditions apply.



Get $2,000 in Free Bets

Register for a new PointsBet account & deposit

Receive a free bet refund up to $500 if your first fixed odds bet loses

& a free bet refund up to $1,500 if your first two PointsBetting Wager loses

Must be 21+. Full terms are available at PointsBet.

Monkey Knife Fight


Claim Instant Deposit Match up to $100 + Free $5 game

Register for a Monkey Knife Fight account & deposit using promo code PICKSWISE100

Monkey Knife Fight will match your first deposit up to $100

Deposit $100 and you'll get $100 bonus + a free $5 game

18+. Terms and conditions apply. You must live in one of the states where real money DFS is legal.

Yahoo DFS


Get $25 in Site Credit With Yahoo DFS When You Deposit $5!

Register for a new account with Yahoo DFS and deposit $5+

Enter a $5 DFS contest

Upon entry, you will receive a bonus $25 in credit into your account!

21+ and new players only. Full terms available from Yahoo DFS.



Get Your First Single-Horse Win Wager Back Up to $200 if you don't win

Register for a new TVG account and make a deposit

Place your first single horse win-type bet up to $200

If your horse doesn't win you'll get a refund up to $300

21+. T&C's apply. Please gamble responsibly.



Get a $200 Sign-Up Bonus with Twinspires Racebook!

Open your account using offer code BET200

$200 bonus cash will be credited in increments of $100 for every $400 wagered

To earn the full $200 bonus players must wager $800 within 30 days

21+. Terms and conditions apply.