Week 18 of the 2025 NFL regular season is on the immediate horizon. That’s right; we have reached the finish line – or 18 teams have reached it, to be exact. 14 will be gearing up for the playoffs following the end of competition on Sunday. There are 2 winner-take-all showdowns, with the victor clinching the division and the loser missing the playoffs. That is the scenario for Panthers vs Buccaneers (unless the Falcons beat the Saints on Sunday, then Carolina wins the NFC South regardless) and Ravens vs Steelers. The Seahawks and 49ers will battle it out on Saturday night for the NFC West title and the #1 seed.
Make sure you check out our NFL predictions as we add our picks on the side and total for every game throughout the week – and throughout the entire season. Also, don’t miss the NFL best bets page for our top picks. For now, let’s break down the NFL Week 18 opening lines and give our best early bet to make.
NFL Week 18 opening lines and odds
Odds available at DraftKings Sportsbook at time of publishing
- Carolina Panthers +3.5 (-115) vs Tampa Bay Buccaneers -3.5 (-105) – Saturday
- Seattle Seahawks -1.5 (-105) vs San Francisco 49ers +1.5 (-115) – Saturday
- Cleveland Browns +7 (-115) vs Cincinnati Bengals -7 (-105)
- Indianapolis Colts +9.5 (-110) vs Houston Texans -9.5 (-110)
- New York Jets +7.5 (-115) vs Chicago Bears -7.5 (-105)
- Green Bay Packers +6 (-110) vs Minnesota Vikings -6 (-110)
- Arizona Cardinals +9.5 (-110) vs Los Angeles Rams -9.5 (-110)
- Tennessee Titans +11.5 (-105) vs Jacksonville Jaguars -11.5 (-115)
- Miami Dolphins +11.5 (-115) vs New England Patriots -11.5 (-105)
- Los Angeles Chargers +7.5 (-110) vs Denver Broncos -7.5 (-110)
- Kansas City Chiefs -5.5 (-110) vs Las Vegas Raiders +5.5 (-110)
- Washington Commanders +8.5 (-115) vs Philadelphia Eagles -8.5 (-105)
- New York Giants -1.5 (-105) vs Las Vegas Raiders +1.5 (-115)
- New Orleans Saints +2.5 (-110) vs Atlanta Falcons -2.5 (-110)
- Detroit Lions +2.5 (-110) vs Chicago Bears -2.5 (-110)
- Baltimore Ravens -3.5 (-105) vs Pittsburgh Steelers +3.5 (-115) – Sunday Night Football
Bet on EVERY NFL Week 18 game with DraftKings Sportsbook, where new users can click here to sign up now and receive $200 in bonus bets INSTANTLY if their first $5 wager is a winner!
Early NFL Week 18 best bet: Kansas City Chiefs -5.5 over Las Vegas Raiders (-110)
Even against a team playing as poorly as Kansas City is right now, Las Vegas is pretty much an automatic fade. When the Raiders are getting less than a touchdown, it’s a can’t-miss opportunity – regardless of the opponent. Head coach Pete Carroll’s squad was horrendous even when it was trying to win. Now it’s making no secret about its disinterest – and perhaps even its desire to lose. In Week 17, the Raiders faced the Giants in what was effectively a battle for the #1 pick in the 2026 NFL Draft. Having already shut down their 2 best players – DE Maxx Crosby and TE Brock Bowers – for the season, Las Vegas unsurprisingly got clobbered 34-10. That’s right; it lost to the other worst team in football by 24 points.
The Chiefs may be wrapping up a disastrous 2025 campaign, but at least you can count on them playing hard through the finish line. Head coach Andy Reid’s club lost to Denver by just 7 points on Christmas in a game that was competitive from start to finish. The offense is terrible with Patrick Mahomes out, but it doesn’t have to be very good to comfortably beat Las Vegas. Moreover, the Chiefs are essentially playing on a mini-bye. Give Reid extra preparation time – even for a meaningless game – and good things usually happen.
Find out our experts’ NFL picks for every game in Week 18 — they’re up +44.4 units this season!
Click here to add us to your Google preferred sources and never miss a story
