Thursday Night Football Betting Guide: Seattle Seahawks vs Arizona Cardinals Expert Picks, Odds & Best Bets for Week 4

UpdatedSep 15, 2026

Reading time2 min

Week 4 of the 2025 NFL season has arrived and we get things started with an NFC West matchup between the Seattle Seahawks and Arizona Cardinals on Thursday Night Football. Both of these teams are 2-1 and will see this as a big opportunity to make a push for the top of the division standings, with the 49ers currently 3-0 but decimated by injuries. Seahawks vs Cardinals kicks off on TNF at 8:15 pm ET live on Amazon Prime Video, and here at Pickswise, we have everything you need to bet better! You can find out our NFL picks on the side and total, along with our experts’ best NFL player prop bets and Same Game Parlay picks. Let’s get into our TNF picks and Seahawks vs Cardinals predictions.

Sign up to bet365 now to bet on Seahawks vs Cardinals on TNF and EVERY NFL game this season! And if you click here to join, you’ll receive $200 in bonus bets INSTANTLY when you make your first $5 bet, regardless of whether it wins or loses!

NFL Seahawks vs Cardinals picks & TNF predictions

Seahawks vs Cardinals predictions — our experts have started the season with a 55-40-1 record on sides and totals for +27 units! Get Chris Farley’s picks for TNF

Best Seahawks vs Cardinals player prop bets

Seahawks vs Cardinals player prop picks — Prop Holliday is 6-2 with his player prop bets to start the 2025 NFL season! Check out his best bets for TNF
Seahawks vs Cardinals touchdown scorer best bets — Caleb Wilfinger’s to predictions to find the end zone at +175 and +190 odds