NFL Best Bets

Get our experts’ best NFL bets this week and every week of the 2025/26 season. Our experts analyze their NFL picks and predictions across a whole host of markets to give you their best NFL Bets today.

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1:00 PM ET
Sun Nov 23
Pittsburgh Steelers
Chicago Bears
Steelers
Bears
Point Spread PickBest Bet
CHI Bears -2.5(-115)

The Chicago Bears have won 7 of their last 8 games heading into a home date with the Pittsburgh Steelers on Sunday afternoon. I’m hopping on the bandwagon, so my Bears vs Steelers pick is on the home side to win and cover. It is fair to say that the Bears have found their stride under first-year head coach Ben Johnson and second-year quarterback Caleb Williams. With Williams playing mistake-free football, D’Andre Swift balancing the offense by running the ball effectively and Johnson’s play-calling working its magic just as it did when he was offensive coordinator in Detroit, Chicago’s offense is humming. It is #4 overall (373.8 yards per game) and #8 in scoring (25.8 points per game). Williams has thrown only 4 interceptions to go along with his 16 total touchdowns (13 passing, 3 rushing).

Pittsburgh’s QB situation is far worse. On Sunday the visitors will either be playing with a banged-up Aaron Rodgers or a backup in Mason Rudolph. Rodgers is questionable after sustaining minor fracture in his left wrist during last week’s victory over Cincinnati. It was announced on Tuesday that that injury will not require surgery. Whatever the case, neither Rodgers nor Rudolph inspires much confidence. On the other side of the ball, the Steelers’ defense is overrated. Everyone just assumes it is good since TJ Watt is on the field, but that is hardly the reality. Head coach Mike Tomlin’s team is #28 league wide in total defense and dead last against the pass. Its 33 sacks are good for third most in the NFL, but keep in mind that Williams is a mobile quarterback who can avoid pressure for the most part. At home against an unspectacular opponent, I feel great about Chicago maintaining momentum.

Pittsburgh Steelers vs Chicago Bears prediction: Bears -2.5 (-115) available at time of publishing. Playable to -3.

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4:05 PM ET
Sun Nov 23
Jacksonville Jaguars
Arizona Cardinals
Jaguars
Cardinals
Point Spread PickBest Bet
JAX Jaguars -2.5(-112)

The Arizona Cardinals have lost 7 of their last 8 games heading into a home date with the Jacksonville Jaguars during Week 12 of the NFL season on Sunday afternoon. Once 2-0, the Cardinals are now 3-7 and aren’t even looking competitive. They have dropped 2 consecutive contests by at least 19 points. Arizona is only a slight underdog against Jacksonville because it is playing at home, but does that really matter? Probably not! After all, the Cards have lost 4 home games in a row — including to the lowly Titans. Tennessee (1-9) has not won a single other game this entire year. This is simply a fantastic time to fade head coach Jonathan Gannon’s squad, so my Jaguars vs Cardinals pick is on the visitors to win and cover.

Jacksonville, on the other hand, is playing solid football. Its worst loss since Week 2 is against the Texans — but even a 1-possession setback on the road in Houston is nothing to be ashamed about. The Jaguars are coming off a 35-6 beatdown of the Chargers this past weekend. It is true that the Bolts’ offensive line is in absolute shambles, but that is still an extremely impressive result any way you slice it. The Jags churned out 192 rushing yards, which bodes well for their chances of finding success against a mediocre Cardinals defense. This is a tale of 2 teams going in opposite directions, and I think that trend will continue on Sunday.

Jacksonville Jaguars vs Arizona Cardinals prediction: Jaguars -2.5 (-112) available at time of publishing. Playable to -3.

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8:15 PM ET
Mon Nov 24
Carolina Panthers
San Francisco 49ers
Panthers
49ers
Point Spread PickBest Bet
SF 49ers -6.5(-115)

Markets and NFL media heads are high on the Panthers after they did something highly unusual: win a big game on the road with Bryce Young under center. Even more unusual was Young’s form. The former Alabama star made Panthers history last Sunday, throwing for a franchise game-high 448 yards and 3 touchdowns in a winning effort at Atlanta. Down 21-10 at halftime, at one point Young had to exit to Carolina’s locker room to address a new ankle injury. Immediately it felt like the same old story; an ailing group under new coach Dave Canales — who can’t quite get it right. The Panthers’ offense caught fire, along with their defense permitting just 92 yards and 6 second-half points. History will see Week 11 as an impressive comeback win for Canales’ group, a roster that’s proving it’s not built the same as previous iterations.

Unfortunately, we’re here to spoil the party. While the Panthers win was impressive, we must consider their opponent. After starting the season looking like a formidable NFC contender, the Falcons loss on Sunday was their fifth in a row. Even worse, Michael Penix Jr., their second-year starter who took over for Kirk Cousins last season, left with what’s likely a season-ending knee injury. Atlanta’s defense has also been floundering for over a month. This Sunday Carolina will face a much bigger road challenge. The 49ers are coming off an inspiring victory on Sunday, one that left their fans hopeful that this season may have a higher ceiling than once thought. San Francisco leveraged 3 Arizona turnovers, but with Brock Purdy back the offense was smooth and explosive — turning 5 red-zone possessions into 4 touchdowns. The Niners clobbered their rivals 41-22 on their enemy’s home field, and — perhaps most importantly — Purdy looked fantastic (19-for-26, 200 yards, 7.7 yards per pass, 3 touchdowns). It was the kind of win that catalyzes future success.

The Panthers deserve a ton of credit for their turnaround this season, but the 49ers still have championship fabric throughout their roster — including a coach and quarterback pairing who are as effective as any in the NFL. The Niners’ offense is also healthier than it’s been all season, with Jauan Jennings, Ricky Pearsall and George Kittle all ready to roll for Week 12. I like the home team to pull away.

Panthers vs 49ers best bet: 49ers -6.5 (-115) available at time of publishing. Playable to 7.

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NFL Best Bets
43.2%
Win %
19Wins
25Losses
1Pushes
Percentage only includes Wins and Losses

At Pickswise our experts put in countless hours of research and analysis every week to bring you free NFL best bets. Although the NFL regular season is just 18 weeks long, there are still 272 regular-season NFL games to decipher, as well as the NFL playoffs, so we bring you free NFL best bets this week and across the whole season and post-season.

Best NFL Bets Today

The NFL action comes thick and fast during the season and we cover all of it. Our NFL Best Bets should be your first port of call here at Pickswise alongside the NFL Picks page where you can find the entire catalog of our weekly game previews which combine for a comprehensive view of all of today’s NFL games and best bets. Check back every week for those Monday Night, Thursday Night and Sunday slates’ best NFL picks, all for free. 

Best NFL Bets This Week

The NFL is very much a look-ahead sport, particularly within sports betting. Almost as soon as the previous week’s games are done, oddsmakers and bettors alike are already trying to find the best bets for NFL this week. Here at Pickswise, we’re no different.

You can often find great value early in the week and our experts will take an early look ahead, so we get our best bets for NFL this week posted on-site as soon as possible, so you can lock in those best lines and odds before the inevitable movement later in the week. Be sure to keep an eye on the NFL best bets page every day on game week as our experts continue to highlight those biggest edges and best NFL bets.

What Is An NFL Best Bet at Pickswise?

Our expert NFL cappers post their best bets on this week’s NFL games across a whole host of betting markets. Each of our selections on Pickswise is given a confidence rating ranging from 1 to 3 stars, with 3 stars being the most confident, and 1 the least. Our NFL Best Bets page details those 3 star rated bets, making them our expert’s NFL Best Bets on this week’s games.

How We Decide Our Best NFL Bets at Pickswise

Each week of the NFL season, as our experts deep-dive into the stats and make their picks and predictions for the week’s coming games each expert handicapper gives their reasoning and the data to back up their selections. Through a robust process of debate and consideration, taking into account the odds, potential winnings and an expert judgement on the bet’s outcome, they come to a consensus on the confidence rating for each play. Only those that get a 3 star confidence rating through this process qualify as an NFL best bet.

All our handicappers vie for their picks to get the NFL best bet stamp, each and every week of the season. It’s this friendly competition amongst experts that ensures are NFL best bets are indeed the best NFL bets you’ll find anywhere.

Where Should I Bet On Your NFL Best Bets Today

Another important strategy for maximizing your NFL betting success is to make sure you have access to the best odds and lines available across all of the best online sportsbooks.

Alongside our NFL best bets, we also highlight the best odds and lines that the sportsbooks are currently offering. This ensures you’re maximizing your chances of turning a profit over time as every half point or fractional odds difference adds up over the season.

For more on our recommended NFL sportsbooks, check out our rankings for the best NFL betting sites. The best odds, a diverse range of NFL betting markets and an overall user-friendly app experience are just some of the key factors we consider.

Unsure where is best to place your online sports wagers? Or looking to make the most of new player bonuses and promo codes? Be sure to check out our
Online Sportsbook Promotions for expert analysis of the best sportsbook welcome offers available in your state. 


57 Wins from 2024/25 NFL Best Bets

When Pickswise tells you that we have an NFL Best Bet, we mean it. In the 2024 season, our team of expert NFL handicappers finished with 57 wins on our NFL best bets and we are hungry to provide even more winners this season. We don’t just throw around 3 star plays, all of our cappers and editors meticulously break down each pick and predictions before we put our NFL best bet stamp on it. We often have best bets each week of the season, but tail our expert NFL cappers with confidence this week. 

Andrew Wilsher, Pickswise Managing Editor

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NFL Best Bets FAQs

There are endless ways in which you can bet on the NFL and the Best Bet is a winning one. The Pickswise Best Bets page is a collation of our expert handicappers’ most confident selections on this week’s NFL games. While we can’t guarantee every bet will win, we have a long-trusted and proven record, our NFL Best Bets returned 57 wins across the 2024/25 season.

The most important numbers to consider when betting on the NFL are 3 and 7. A lot of games in the NFL are decided by one score so when you’re looking at spread lines you must keep Field Goals and Touchdowns at the forefront of your mind, as there is a big difference between -3.5 and -2.5 and -6.5 and -7.5.

At Pickswise we use a star system to show our cappers’ confidence in that particular pick. All of our Best NFL Bets get our top confidence rating of 3 stars.