NFL Best Bets

It’s hard to even describe just how good the Texans’ defense is. Perhaps the most telling way to say it is that the unit is so good that you might actually tune into a football game for the purpose of watching defense instead of offense. Yes, the Texans’ defense is legitimately fun to watch — and it is the main reason why my Cardinals vs Texans pick is Under 42.5. They have recorded 36 sacks and have forced 22 turnovers (fourth most in the league). Moreover, the offense has committed the third-fewest turnovers in the NFL (10) — so it rarely puts the defense in bad situations. Speaking of the offense, quarterback C.J. Stroud has been solid but unspectacular in 2 starts since missing 3 games with concussion. In those 2 appearances he went a combined 37-of-66 for 479 yards, 1 TD and 1 INT.

Meanwhile, Brissett is playing well for the Cardinals but is not getting much help at all from the running game. And no matter what Brissett brings to the table on Sunday, it’s hard to like any offense’s chances against Houston at the moment. Will Anderson Jr., Danielle Hunter and others are probably going to wreak havoc in the backfield. I’m not even entirely positive that Arizona will avoid getting shut out. The under is 4-0 in the Texans’ last four overall and 2-0 in the last two head-to-head encounters.

Arizona Cardinals vs Houston Texans prediction: Under 42.5 (-108) available at time of publishing. Playable to -40.5.

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It will be a showdown in the NFC South when the Carolina Panthers visit the New Orleans Saints on Sunday afternoon. New Orleans did Carolina a solid by upsetting division-rival Tampa Bay in Week 14, but the Panthers won’t return the favor by playing nice this weekend. After all, they are now in the thick of a division race. The door is open for the Panthers and — at least for the time being — I expect them to walk through it. My Panthers vs Saints pick is for the visitors to win and cover. This is a fantastic spot for the visitors. Carolina is coming off a bye and facing an opponent that just picked up its biggest win of the season, thus inflating its value.

The Saints are very bad — way worse than this 2.5-point spread indicates. Their season-long sample size confirms that this is a far inferior team compared to what was on display at Tampa Bay this past weekend. The Bucs really aren’t that good, either. In fact, they have been in shambles since a hot start to the 2025 campaign — their record since a Week 9 bye is 1-4. The Saints gained only 260 yards of total offense but still managed to prevail 24-20. Now they return to the Big Easy, but their is no home-field advantage for them these days. They are 1-5 at the Mercedes-Benz Dome this season compared to 2-5 on the road. Meanwhile, the Panthers are 6-3 SU in their last 9 overall and find themselves tied atop the NFC South with the Bucs. Carolina most recently stunned the Rams in Week 13 as Bryce Young continued to heat up. Young has thrown at least 3 touchdown passes in 4 games so far in 2025.

Carolina Panthers vs New Orleans Saints prediction: Panthers -2.5 (-115) available at time of publishing. Playable to -3.

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