NFL Best Bets

Get our experts’ best NFL bets this week and every week of the 2025/26 season. Our experts analyze their NFL picks and predictions across a whole host of markets to give you their best NFL Bets today.

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4:30 PM ET
Sun Jan 11
San Francisco 49ers
Philadelphia Eagles
49ers
Eagles
Point Spread PickBest Bet
SF 49ers +4.5(-110)

The San Francisco 49ers (12-5) withstood a bunch of injuries to key players this season, including QB Brock Purdy missing 8 games. The Niners had an opportunity at the top seed in the NFC before falling at home to the Seahawks last Saturday, 13-3. San Francisco fell to the 6th seed, getting set to face the defending champion Philadelphia Eagles (11-6). There were plenty of ups and downs for the Eagles, including 3 winning streaks of 3 games and a losing skid of 3 games, but they managed to grab the NFC East title for a 2nd straight season.

Philadelphia and San Francisco each finished with 10-7 ATS marks, while the Niners won 7 of 9 games away from Levi’s Stadium. Head coach Kyle Shanahan’s squad beat the Seahawks and Rams on the road in the first 5 weeks, but the other 5 away victories came against teams with losing records. The 49ers posted a 2-4 ATS ledger in the underdog role, which included an overtime triumph over the Rams as a 6.5-point dog in Week 5. The Eagles compiled a 4-4 ATS record at Lincoln Financial Field, including outright defeats to the Broncos and Bears. Philadelphia ranked 24th in yards per game (311.2), the 3rd-fewest for any playoff team after ranking 8th in this category during its Super Bowl run last season.

These teams last met in December 2023 when the Niners roughed up the Eagles at the Linc 42-19 as 3.5-point road favorites. Purdy threw 4 TD passes, while now-departed WR Deebo Samuel scored 3 times. In their last playoff matchup in the 2022 NFC Championship, the Eagles shredded the 49ers 31-7, but Purdy was hurt early and San Francisco was forced to run the ball basically the entire game. The Niners are 6-3 in the playoffs under Shanahan since 2021 and have not been bounced in their first game. Let’s back the 49ers with the points against the defending champs.

49ers vs Eagles best bet: San Francisco 49ers +4.5 (-110) available at time of publishing. Playable to 3.5.

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8:15 PM ET
Mon Jan 12
Houston Texans
Pittsburgh Steelers
Texans
Steelers
Game Totals PickBest Bet
Under 39.5(-110)

Pittsburgh will be predictably cold, well-under freezing, for this Monday night battle. We wouldn’t have it any other way. While the Steelers’ defense hasn’t exactly played up to its standards (see 2 remarkably bad blown coverages last week against Baltimore, resulting in 2 of the easiest touchdowns you’ll ever see), it’s also clear that the talent is there. Cameron Hayward, the defense’s team captain, was stellar in key moments last Sunday night, stifling Derrick Henry runs and in Lamar Jackson’s face for most of the contest. He had 7 tackles. Others made big plays, too. While the Steelers lack consistency in their secondary, their front-seven is as formidable as any in the NFL. After starting the season well below expectations, they’ve climbed to 12th overall in sacks, accruing 3 more last week against the ultra-elusive Jackson. Houston’s offense is below average (23rd in total EPA metrics), which means the Steelers have a chance to keep this game within distance.

On Monday, they’ll have a greater onus to hold up their team, since the Steelers’ offense will be facing arguably the league’s best unit. Despite finishing the season with a perplexing performance against the Colts (they allowed a Riley Leonard-led offense to drop 30 points on 354 yards — what?), Houston’s defense has been their stalwart unit all season. Aaron Rodgers enjoyed a comfortable pocket for nearly the entire game in Week 18, an experience that will almost certainly not repeat in this Wild Card battle. The Texans are ferocious at the line of scrimmage, #1 in the NFL in pressures and 8th overall in sack percentage (8.03%). They’re also top-3 in takeaways and 2nd in turnover margin. If the Steelers’ offense, a group that’s already simplistic and limited (16th in EPA per pass, 26th in rush yards per game), wants to succeed, they’ll need to apply maximum creativity and perfect execution. 

The fact that Pittsburgh is led by one of the greatest arms in NFL history gives their offense a shot, but we still don’t feel good about the matchup. Either way, both defenses are in a much better situation. This is our favorite bet of the entire Wild Card Weekend.

Texans vs Steelers best bet: Under 39.5 (-110) available at time of publishing. Playable to 38.

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NFL Best Bets
50.7%
Win %
36Wins
35Losses
1Pushes
Percentage only includes Wins and Losses

At Pickswise our experts put in countless hours of research and analysis every week to bring you free NFL best bets. Although the NFL regular season is just 18 weeks long, there are still 272 regular-season NFL games to decipher, as well as the NFL playoffs, so we bring you free NFL best bets this week and across the whole season and post-season.

Best NFL Bets Today

The NFL action comes thick and fast during the season and we cover all of it. Our NFL Best Bets should be your first port of call here at Pickswise alongside the NFL Picks page where you can find the entire catalog of our weekly game previews which combine for a comprehensive view of all of today’s NFL games and best bets. Check back every week for those Monday Night, Thursday Night and Sunday slates’ best NFL picks, all for free. 

Best NFL Bets This Week

The NFL is very much a look-ahead sport, particularly within sports betting. Almost as soon as the previous week’s games are done, oddsmakers and bettors alike are already trying to find the best bets for NFL this week. Here at Pickswise, we’re no different.

You can often find great value early in the week and our experts will take an early look ahead, so we get our best bets for NFL this week posted on-site as soon as possible, so you can lock in those best lines and odds before the inevitable movement later in the week. Be sure to keep an eye on the NFL best bets page every day on game week as our experts continue to highlight those biggest edges and best NFL bets.

What Is An NFL Best Bet at Pickswise?

Our expert NFL cappers post their best bets on this week’s NFL games across a whole host of betting markets. Each of our selections on Pickswise is given a confidence rating ranging from 1 to 3 stars, with 3 stars being the most confident, and 1 the least. Our NFL Best Bets page details those 3 star rated bets, making them our expert’s NFL Best Bets on this week’s games.

How We Decide Our Best NFL Bets at Pickswise

Each week of the NFL season, as our experts deep-dive into the stats and make their picks and predictions for the week’s coming games each expert handicapper gives their reasoning and the data to back up their selections. Through a robust process of debate and consideration, taking into account the odds, potential winnings and an expert judgement on the bet’s outcome, they come to a consensus on the confidence rating for each play. Only those that get a 3 star confidence rating through this process qualify as an NFL best bet.

All our handicappers vie for their picks to get the NFL best bet stamp, each and every week of the season. It’s this friendly competition amongst experts that ensures are NFL best bets are indeed the best NFL bets you’ll find anywhere.

Where Should I Bet On Your NFL Best Bets Today

Another important strategy for maximizing your NFL betting success is to make sure you have access to the best odds and lines available across all of the best online sportsbooks.

Alongside our NFL best bets, we also highlight the best odds and lines that the sportsbooks are currently offering. This ensures you’re maximizing your chances of turning a profit over time as every half point or fractional odds difference adds up over the season.

For more on our recommended NFL sportsbooks, check out our rankings for the best NFL betting sites. The best odds, a diverse range of NFL betting markets and an overall user-friendly app experience are just some of the key factors we consider.

Unsure where is best to place your online sports wagers? Or looking to make the most of new player bonuses and promo codes? Be sure to check out our
Online Sportsbook Promotions for expert analysis of the best sportsbook welcome offers available in your state. 


57 Wins from 2024/25 NFL Best Bets

When Pickswise tells you that we have an NFL Best Bet, we mean it. In the 2024 season, our team of expert NFL handicappers finished with 57 wins on our NFL best bets and we are hungry to provide even more winners this season. We don’t just throw around 3 star plays, all of our cappers and editors meticulously break down each pick and predictions before we put our NFL best bet stamp on it. We often have best bets each week of the season, but tail our expert NFL cappers with confidence this week. 

Andrew Wilsher, Pickswise Managing Editor

NFL Playoff Picks
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NFL Divisional Round Picks
NFL Conference Championship Picks

NFL Best Bets FAQs

There are endless ways in which you can bet on the NFL and the Best Bet is a winning one. The Pickswise Best Bets page is a collation of our expert handicappers’ most confident selections on this week’s NFL games. While we can’t guarantee every bet will win, we have a long-trusted and proven record, our NFL Best Bets returned 57 wins across the 2024/25 season.

The most important numbers to consider when betting on the NFL are 3 and 7. A lot of games in the NFL are decided by one score so when you’re looking at spread lines you must keep Field Goals and Touchdowns at the forefront of your mind, as there is a big difference between -3.5 and -2.5 and -6.5 and -7.5.

At Pickswise we use a star system to show our cappers’ confidence in that particular pick. All of our Best NFL Bets get our top confidence rating of 3 stars.