NFL Best Bets

Get our experts’ best NFL bets this week and every week of the 2025/26 season. Our experts analyze their NFL picks and predictions across a whole host of markets to find you their best NFL Bets today.

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8:15 PM ET

Mon Sep 22

Lions

Ravens

Point Spread PickBest Bet

BAL Ravens -4.5(-115)

Reasoning

You may have heard it before, but the Ravens are pretty good against NFC opponents. In the era of Lamar Jackson, Baltimore is 24-2 when the 2-time MVP starts. That’s gone on far too long to ignore, so there must be something to it. The reality is we often find Baltimore stumbling against familiar opponents like the Browns and Steelers, or the Bills (too soon?).

Against unfamiliar opponents, Jackson and his comrades seem to settle in more easily and freely in their playing style. The result has been catastrophic for their NFC foes, with the Eagles last year and the Giants 3 years ago as the only programs to overcome the juggernaut. And the Ravens often win in dominant fashion. Take 2 years ago, for example, the same season where the Lions went 12-5 and ascended to an NFC championship game. When they traveled to Baltimore in Week 7, they were decimated, 38-6. Jackson had 4 total touchdowns and 327 passing yards on just 27 attempts.

History doesn’t always repeat, but the Ravens seemed to return to form last Sunday; that’s not a good sign for Detroit. After a slow-moving first half, Baltimore dominated Cleveland and covered a 12-point spread by double digits. Their defense was particularly effective, allowing just 4.4 yards per pass to Joe Flacco.

Of course, Detroit was even more impressive in Week 2, obliterating the hapless Bears and posting a 52-point scoreboard in a loud response to their Week 1 failure. Detroit may not be of the exact same caliber this season, but they’re still good enough to stomp on opponents at home. On the road will likely be a different story, especially against a Ravens’ team that gets to stay in Charm City, rest and refine their product for 2 weeks leading into this battle. Detroit is an above-average team, but the Ravens are a different animal in these scenarios.

Lions vs Ravens best bet: Ravens -4.5 (-115) available at time of publishing. Playable to 5.5.

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BET -5.5 NOW WITH

Chris R. Farley

NFL Best Bets

57.1%

Win %

4Wins

3Losses

0Pushes

Percentage only includes Wins and Losses

At Pickswise our experts put in countless hours of research and analysis every week to bring you free NFL best bets. Although the NFL regular season is just 18 weeks long, there are still 272 regular-season NFL games to decipher, as well as the NFL playoffs, so we bring you free NFL best bets this week and across the whole season and post-season.

Best NFL Bets Today

The NFL action comes thick and fast during the season and we cover all of it. Our NFL Best Bets should be your first port of call here at Pickswise alongside the NFL Picks page where you can find the entire catalog of our weekly game previews which combine for a comprehensive view of all of today’s NFL games and best bets. Check back every week for those Monday Night, Thursday Night and Sunday slates’ best NFL picks, all for free.

Best NFL Bets This Week

The NFL is very much a look-ahead sport, particularly within sports betting. Almost as soon as the previous week’s games are done, oddsmakers and bettors alike are already trying to find the best bets for NFL this week. Here at Pickswise, we’re no different.

You can often find great value early in the week and our experts will take an early look ahead, so we get our best bets for NFL this week posted on-site as soon as possible, so you can lock in those best lines and odds before the inevitable movement later in the week. Be sure to keep an eye on the NFL best bets page every day on game week as our experts continue to highlight those biggest edges and best NFL bets.

What Is An NFL Best Bet at Pickswise?

Our expert NFL cappers post their best bets on this week’s NFL games across a whole host of betting markets. Each of our selections on Pickswise is given a confidence rating ranging from 1 to 3 stars, with 3 stars being the most confident, and 1 the least. Our NFL Best Bets page details those 3 star rated bets, making them our expert’s NFL Best Bets on this week’s games.

How We Decide Our Best NFL Bets at Pickswise

Each week of the NFL season, as our experts deep-dive into the stats and make their picks and predictions for the week’s coming games each expert handicapper gives their reasoning and the data to back up their selections. Through a robust process of debate and consideration, taking into account the odds, potential winnings and an expert judgement on the bet’s outcome, they come to a consensus on the confidence rating for each play. Only those that get a 3 star confidence rating through this process qualify as an NFL best bet.

All our handicappers vie for their picks to get the NFL best bet stamp, each and every week of the season. It’s this friendly competition amongst experts that ensures are NFL best bets are indeed the best NFL bets you’ll find anywhere.

Where Should I Bet On Your NFL Best Bets Today

Another important strategy for maximizing your NFL betting success is to make sure you have access to the best odds and lines available across all of the best online sportsbooks.

Alongside our NFL best bets, we also highlight the best odds and lines that the sportsbooks are currently offering. This ensures you’re maximizing your chances of turning a profit over time as every half point or fractional odds difference adds up over the season.

For more on our recommended NFL sportsbooks, check out our rankings for the best NFL betting sites. The best odds, a diverse range of NFL betting markets and an overall user-friendly app experience are just some of the key factors we consider.

Unsure where is best to place your online sports wagers? Or looking to make the most of new player bonuses and promo codes? Be sure to check out our Online Sportsbook Promotions for expert analysis of the best sportsbook welcome offers available in your state.

57 Wins from 2024/25 NFL Best Bets

When Pickswise tells you that we have an NFL Best Bet, we mean it. In the 2024 season, our team of expert NFL handicappers finished with 57 wins on our NFL best bets and we are hungry to provide even more winners this season. We don’t just throw around 3 star plays, all of our cappers and editors meticulously break down each pick and predictions before we put our NFL best bet stamp on it. We often have best bets each week of the season, but tail our expert NFL cappers with confidence this week.

Andrew Wilsher, Pickswise Managing Editor

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NFL Best Bets FAQs

What Is The Best Bet On In The NFL?

There are endless ways in which you can bet on the NFL and the Best Bet is a winning one. The Pickswise Best Bets page is a collation of our expert handicappers’ most confident selections on this week’s NFL games. While we can’t guarantee every bet will win, we have a long-trusted and proven record, our NFL Best Bets returned 57 wins across the 2024/25 season.

What Are The Best Numbers To Bet For NFL?

The most important numbers to consider when betting on the NFL are 3 and 7. A lot of games in the NFL are decided by one score so when you’re looking at spread lines you must keep Field Goals and Touchdowns at the forefront of your mind, as there is a big difference between -3.5 and -2.5 and -6.5 and -7.5.

How Do I Know What The Best NFL Bets Are

At Pickswise we use a star system to show our cappers’ confidence in that particular pick. All of our Best NFL Bets get our top confidence rating of 3 stars.