NFL Best Bets

Get our experts’ best NFL bets this week and every week of the 2025/26 season. Our experts analyze their NFL picks and predictions across a whole host of markets to find you their best NFL Bets today.

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1:00 PM ET
Today
Carolina Panthers
Green Bay Packers
Panthers
Packers
Point Spread PickBest Bet
GB Packers -13.0(-110)

The Green Bay Packers enter this one rolling after their big win over Aaron Rodgers and the Steelers on Sunday Night Football, and will look to keep it going here against the Carolina Panthers, who appear to be getting Bryce Young back for this one. Young practiced fully this week, and appears set to return after a brief absence. For several reasons, I’m not optimistic about how his return will go. Young on the road at Lambeau at less than 100 percent health against a talented Green Bay defense led by Micah Parsons is a recipe for disaster.

Young almost always struggles with pressure, and with Rashan Gary and Parsons the Packers have quite the pass-rushing duo. Those two combined to sack Rodgers 3 times last week, and almost got him a bunch of other times. 4 of Green Bay’s 5 wins this season have come by 9+ points, so I’m not worried about their ability to run up the score against an inferior opponent like the Panthers. There was some talk that Carolina was much improved this season, but I was never buying it. 3 of their 4 wins this year were by extremely narrow margins against Dolphins, Cowboys and Jets teams that were struggling mightily, and the other was against the Falcons who they always randomly play well against.

Reality came crashing in last week when they were demolished at home by 31 points by a Bills team that certainly hasn’t looked unstoppable this year. Besides Tetairoa McMillan, there are virtually no pass-catchers to speak of on the roster. In fact, no other Panthers player has more than 159 yards receiving through 8 games, which is pretty insane. And McMillan is a rookie who has by no means been dominant and can’t be counted on to carry literally the entire load for the passing game. I don’t see many reasons to believe this one will be close.

Panthers vs Packers prediction: Green Bay Packers -13 (-110) at the time of publishing. Playable at that number or better.

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1:00 PM ET
Today
San Francisco 49ers
New York Giants
49ers
Giants
Game Totals PickBest Bet
Under 48.5(-105)

It shouldn’t matter whether it’s Purdy or Jones under center for San Francisco. The offense does not inspire a whole lot of confidence with either guy running the show. McCaffrey is obviously great, but even though he has stayed healthy this season the running game has been pretty much nonexistent. The Stanford product is more of a receiver for this team. In fact, he is averaging just 3.5 yards per carry. As such, it may not matter that the Giants are terrible against the pass; the fact that they are decent against the pass (6.7 yards per attempt allowed) bodes well for their chances of containing the 49ers. That is part of the reason why my 49ers vs Giants pick is under 48.5.

Skattebo’s absence should not hurt significantly, but it also doesn’t help my any means. It’s also an emotional letdown — especially for Dart. I don’t care how promising the Ole Miss product looks as a rookie; when you are missing your RB1 and WR1 (Malik Nabers is out for the year with a torn ACL), it’s a problem. San Francisco’s defense ranks #11 against the pass and #13 in yards per rushing attempt allowed, so it’s a unit that does not have any huge holes even though it has been dealing with all kinds of injuries. That’s a testament to the acumen of defensive coordinator Robert Saleh. I think all signs point to a relatively low-scoring affair on Sunday.

49ers vs Giants prediction: Under 48.5 (-105) available at time of publishing. Playable to 47.

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4:05 PM ET
Today
Jacksonville Jaguars
Las Vegas Raiders
Jaguars
Raiders
Point Spread PickBest Bet
JAX Jaguars -3.0(+100)

The Jacksonville Jaguars (4-3) were on top of the world after rallying from a 14-0 deficit to stun the Kansas City Chiefs, 31-28 in Week 5. However, the Jags have dropped their last two games to the Seahawks and Rams, as Jacksonville heads to Las Vegas following the bye week. The Raiders (2-5) are also off the bye, as they were shut out by the Chiefs, 31-0 in Week 7. Jacksonville traveled to London in Week 7 to face the Rams and were blown out, 35-7. For the exception of rookie WR Travis Hunter scoring his first NFL touchdown, there weren’t many highlights for the Jags. Following consecutive outings of 26 points against San Francisco and 31 points against Kansas City, the Jaguars combined for 19 points in their last two losses.

The Raiders somehow beat the Patriots in Week 1 on the road, but Las Vegas has lost five of its past six games. Pete Carroll’s team has been held to six points in its last two losses, but busted out for 20 points in its second victory of the season against Tennessee in Week 6. QB Geno Smith has struggled this season, throwing for less than 200 yards in four of six games since posting 362 yards in the Week 1 win at New England. These teams met late last season at Allegiant Stadium, as the Raiders held off the Jaguars, 19-14. However, the two starting quarterbacks for that game were Mac Jones for Jacksonville and Aidan O’Connell for Las Vegas. Jaguars’ QB Trevor Lawrence threw for a season-best 296 yards against the Rams, but also posted a season-low completion percentage of 47.9%. The last 4 losses for the Raiders as an underdog came by 31, 34, 17, and 11 points. After Jacksonville has struggled the last 2 games against 2 solid NFC West teams, this is a good spot to back them as a road favorite to beat Las Vegas.

Jacksonville Jaguars vs Las Vegas Raiders prediction: Jaguars -3 (+100) available at time of publishing. Playable at that number.

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8:20 PM ET
Today
Seattle Seahawks
Washington Commanders
Seahawks
Commanders
Point Spread PickBest Bet
WAS Commanders +3.5(-120)

NFL media is all over the Washington Commanders right now. Fresh off the heels of an embarrassing showing on Monday Night Football in which they lost 7-28 at Kansas City, injuries and concerns about their postseason chances are flooding news outlets. Last season, Jayden Daniels was the popular new kid at school. He was flashy, calm, and unflappable even as a rookie in the postseason. But injuries, including multiple to Daniels this season, have started to derail hope.

Last week it got worse. They only managed to gain 260 total yards and 14 first downs, routinely failing to get into scoring range (just 1/2 in the red-zone) and putting their defense on the field far too often (KC led time of possession 34-26). Even more problematic is their new slew of injuries: kicker Matt Gay has back issues, All-Pro lineman Laremy Tunsil left Monday with a hamstring problem, Terry McClaurin returned on Monday but reportedly felt uncertain about his quad issues following the contest, and, at this juncture, we’re still not sure if Daniels will play in Week 9. According to Dan Quinn, their enigmatic starting QB is expected to practice on Wednesday.

In short, this feels like an “all-in” type of game for the Commanders, who could fall to 3-7 if they lose their next 2 battles (vs. SEA, vs. DET). They’ll be the underdogs in each matchup, and they know they need to win now.

In complete contrast to their foe, Seattle is coming off their bye-week with seemingly no issues. Pro Football Focus ranks the Seahawks as the 2nd-best program in the NFL, #2 on offense and #7 on defense. They have no notable injuries, with perennially banged up Devon Witherspoon and Julian Love trending in the right direction. Perhaps most impressive is their passing prowess, a catalyst to a surprising top-5 offense that brings a #1 ranked 9.0 yards per pass into the nation’s capitol on Sunday night. 

This is the time of year where desperate teams play much better. Judging by Quinn’s comments, it looks like Jayden Daniels will be in line to play on Sunday night. Most of Washington’s injured players are questionable and trending in the right direction, and they’re back in DC until December 7th – over a full month of hometown comforts to get right. In the back of our minds, we still know what Daniels and the Commanders are capable of, and now their backs are against the wall. This is simply a spot to take the underdog, regardless of what the analytics suggest.

Seahawks vs Commanders best bet: Washington Commanders +3.5 (-120) available at time of publishing. Playable to 3.

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8:15 PM ET
Tomorrow
Arizona Cardinals
Dallas Cowboys
Cardinals
Cowboys
Game Totals PickBest Bet
Over 53.0(-120)

To allege that the Cardinals might be able to slow down or limit the Cowboys’ offense, we would need substantial evidence to support such a claim. Unfortunately for Arizona fans, that doesn’t exist. While the visiting team has some respectable marks, like their 6th-place ranking in opponent third-down conversion rate (35.29%) and 7th-place ranking in opponent yards per pass (6.5), most data points suggest that they’re average at best. They are 13th in opponent points (22) and 19th in opponent yards per game (335.7), but even that data is somewhat positively skewed since they’ve faced poor offenses like New Orleans, Carolina, Tennessee, and a tremendously-injured 49ers’ roster in Week 3 (and they still lost). Against superior offenses like Seattle, Indianapolis and Green Bay, the Cardinals permitted 27 points per game.

The Cowboys are statistically better than all of those NFL offenses but the Colts, and they’re far better than every program at home. Putting up 41 points per game at AT&T Stadium is one thing, averaging 441 yards at home is another. The addition of George Pickens has meant a significant uptick in production for Dak Prescott and their air-attack, a receiver that started to shine when CeeDee Lamb had to sit out in 4 contests this season. Now Pickens and Lamb are both healthy and apparently thick as thieves, 2 buddies who make it their goal to punish enemy defenses every week. Together they’ve accrued 1,091 yards and 7 touchdowns. On Monday they’ll battle a defense that’s 27th in opponent pass completion percentage (62.05%) and 25th in opponent pass yards per game (234.9). Without any weather interruptions, there is only one way to look.

Cardinals vs Cowboys prediction: Over 53 (-120) available at time of publishing. Playable to 54.5.

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NFL Best Bets
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Percentage only includes Wins and Losses

At Pickswise our experts put in countless hours of research and analysis every week to bring you free NFL best bets. Although the NFL regular season is just 18 weeks long, there are still 272 regular-season NFL games to decipher, as well as the NFL playoffs, so we bring you free NFL best bets this week and across the whole season and post-season.

Best NFL Bets Today

The NFL action comes thick and fast during the season and we cover all of it. Our NFL Best Bets should be your first port of call here at Pickswise alongside the NFL Picks page where you can find the entire catalog of our weekly game previews which combine for a comprehensive view of all of today’s NFL games and best bets. Check back every week for those Monday Night, Thursday Night and Sunday slates’ best NFL picks, all for free. 

Best NFL Bets This Week

The NFL is very much a look-ahead sport, particularly within sports betting. Almost as soon as the previous week’s games are done, oddsmakers and bettors alike are already trying to find the best bets for NFL this week. Here at Pickswise, we’re no different.

You can often find great value early in the week and our experts will take an early look ahead, so we get our best bets for NFL this week posted on-site as soon as possible, so you can lock in those best lines and odds before the inevitable movement later in the week. Be sure to keep an eye on the NFL best bets page every day on game week as our experts continue to highlight those biggest edges and best NFL bets.

What Is An NFL Best Bet at Pickswise?

Our expert NFL cappers post their best bets on this week’s NFL games across a whole host of betting markets. Each of our selections on Pickswise is given a confidence rating ranging from 1 to 3 stars, with 3 stars being the most confident, and 1 the least. Our NFL Best Bets page details those 3 star rated bets, making them our expert’s NFL Best Bets on this week’s games.

How We Decide Our Best NFL Bets at Pickswise

Each week of the NFL season, as our experts deep-dive into the stats and make their picks and predictions for the week’s coming games each expert handicapper gives their reasoning and the data to back up their selections. Through a robust process of debate and consideration, taking into account the odds, potential winnings and an expert judgement on the bet’s outcome, they come to a consensus on the confidence rating for each play. Only those that get a 3 star confidence rating through this process qualify as an NFL best bet.

All our handicappers vie for their picks to get the NFL best bet stamp, each and every week of the season. It’s this friendly competition amongst experts that ensures are NFL best bets are indeed the best NFL bets you’ll find anywhere.

Where Should I Bet On Your NFL Best Bets Today

Another important strategy for maximizing your NFL betting success is to make sure you have access to the best odds and lines available across all of the best online sportsbooks.

Alongside our NFL best bets, we also highlight the best odds and lines that the sportsbooks are currently offering. This ensures you’re maximizing your chances of turning a profit over time as every half point or fractional odds difference adds up over the season.

For more on our recommended NFL sportsbooks, check out our rankings for the best NFL betting sites. The best odds, a diverse range of NFL betting markets and an overall user-friendly app experience are just some of the key factors we consider.

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Online Sportsbook Promotions for expert analysis of the best sportsbook welcome offers available in your state. 


57 Wins from 2024/25 NFL Best Bets

When Pickswise tells you that we have an NFL Best Bet, we mean it. In the 2024 season, our team of expert NFL handicappers finished with 57 wins on our NFL best bets and we are hungry to provide even more winners this season. We don’t just throw around 3 star plays, all of our cappers and editors meticulously break down each pick and predictions before we put our NFL best bet stamp on it. We often have best bets each week of the season, but tail our expert NFL cappers with confidence this week. 

Andrew Wilsher, Pickswise Managing Editor

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NFL Best Bets FAQs

There are endless ways in which you can bet on the NFL and the Best Bet is a winning one. The Pickswise Best Bets page is a collation of our expert handicappers’ most confident selections on this week’s NFL games. While we can’t guarantee every bet will win, we have a long-trusted and proven record, our NFL Best Bets returned 57 wins across the 2024/25 season.

The most important numbers to consider when betting on the NFL are 3 and 7. A lot of games in the NFL are decided by one score so when you’re looking at spread lines you must keep Field Goals and Touchdowns at the forefront of your mind, as there is a big difference between -3.5 and -2.5 and -6.5 and -7.5.

At Pickswise we use a star system to show our cappers’ confidence in that particular pick. All of our Best NFL Bets get our top confidence rating of 3 stars.

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