Bills vs Vikings Predictions, Picks, Odds & Betting Guide
NFL Week 9 concludes with a potential Super Bowl preview on Monday Night Football, as the 6-1 Buffalo Bills travel to Minnesota to battle the 6-1 Vikings. Both teams have made strong starts to the season for very different reasons - the Bills with their relentless offense and the Vikings with their shut-down defense. But which side of the ball will prove superior in this one?
Bills vs Vikings kicks off at 8:15 PM ET tonight live on ESPN, and we've got everything you need to bet on this huge MNF matchup. You can find out our expert NFL picks on the side and total for this game, along with every matchup throughout the entire season. Plus, we have Bobby Stanley's best NFL player prop bets for MNF, plus Justin Martin's anytime touchdown scorer predictions and Ricky Dimon's Bills vs Vikings Same Game Parlay picks! Let’s break it all down.
Bills vs Vikings Latest MNF Odds
Odds courtesy of bet365 and available at 09:45 AM ET on Monday, November 9. Find out the latest NFL odds for every Week 10 matchup.
Money Line: Bills (-178) vs Vikings (+149)
Point Spread: Bills -3.5 (-101) vs Vikings +3.5 (-119)
Game Totals: Over 44.5 (-107), Under 44.5 (-113)
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Bills vs Vikings Predictions & Picks
Chris Farley’s Bills vs Vikings Spread Pick: Bills -3 (-115)
Both teams have started the season hot at 6-1, but one is not like the other. The Bills rank #1 in points per game (33.3) and #2 in yards per game (393.1). The Vikings rank 26th or worse in a variety of important offensive categories. While Minnesota's defense is legit, the Bills are the much more capable Super Bowl contender, and should prove that here as they outscore the Vikings enough to pull clear.
Chris Farley’s Bills vs Vikings Total Prediction: Under 44.5 (-115)
The Bills' games this season are averaging a whopping 59 points, but we should see some regression as they face an elite Vikings defense that allows the fewest explosive plays in the NFL at home and only 4.7 yards per play. Meanwhile, Minnesota's offense is only averaging 4.7 yards per play itself, which is 29th in the league. We should still see some fireworks, but expect points to be a little more rare as two powerhouses go head-to-head.
Don't miss pro NFL bettor Chris Farley's Bills vs Vikings predictions on the side and total for MNF, with our experts boasting an 11-3 record on their ATS picks so far in Week 9!
Bills vs Vikings Player Prop Bets
Best Bills vs Vikings Player Prop Bet: Khalil Shakir (BUF) Over 38.5 Receiving Yards (-114)
Stop me if you've heard this before: the Vikings blitz more than any team in the NFL. I'm using this information to grab Josh Allen's favorite receiver against the blitz in Khalil Shakir. Per Fantasy Points Data, when Allen is blitzed, Shakir sees 29% targets per routes run (+10% vs non-blitz). Also, his yards per routes run against the blitz is 3.6 (+2.3 vs non-blitz). Shakir's median yardage on the season is 57 per game, and I think he benefits from Moore's return.
Find out who else Bobby Stanley is targeting in his best Bills vs Vikings player prop bets for MNF
Bills vs Vikings TD scorer Best Bet: Jordan Addison (MIN) Anytime Touchdown Scorer (+290)
With Carson Wentz running the show on Monday Night Football, pass catchers like Justin Jefferson and Jordan Addison should get a boost. Wentz had massive passing-yard games last season, as well as in Week 1 against the Packers when Wentz replaced Kyler Murray. Wentz and Addison had multiple connections last season, including games of 4/114 and 5/41/1.
Get the rest of TD expert Justin Martin's Bills vs Vikings anytime touchdown scorer best bets, featuring another pick at +320
Buffalo Bills vs Minnesota Vikings Same Game Parlay
Bills -3 over Vikings (-105)
This should be a fascinating matchup of strength vs strength and weakness vs weakness. The Bills’ offense is amazing, but the Vikings bring one of the best defenses to the table; the Vikings’ offense stinks, but the Bills have a defense that can give up points to anyone. In this case, I’m rolling with offense. Buffalo is #1 in the entire NFL in scoring (33.3 points per game) and #2 in yards (393.1 per game). Minnesota is coming off a tough, physical matchup against NFC North rival Detroit and it resulted in the Vikings’ first loss of the season – an ugly 19-15 decision. I can’t see the Vikes keeping up with the Bills’ high-octane attack.
James Cook (BUF) Over 83.5 Rushing Yards (-114) and to Score a Touchdown (-105)
Minnesota is incredible against the pass. The unit can, however, be attacked on the ground. The Vikings are giving up 116.7 rushing yards per contest on 4.5 yards per carry (ninth-most). Cook has been awesome so far in 2026 and should be able to take advantage of a nice opportunity. The Georgia product has racked up 707 rushing yards through seven games and has not rushed for fewer than 75 yards since Week 1. He has scored seven touchdowns and has not been kept out of the end zone since the season opener.
Carson Wentz (MIN) Over 209.5 Passing Yards (-113)
This actually works quite nicely with the Bills covering. After all, a negative game script for the Vikings – which is anticipated – calls for them to be playing from behind and therefore taking to the air. Although Wentz is nothing special at this point in his career, 209.5 is not a particularly big number. In five appearances last year, the former North Dakota State standout threw for 313 yards or more twice. He is still a serviceable NFL signal-caller. As for Buffalo’s pass defense, it is third-to-last in the league at 254.7 yards per game allowed.
Bills vs Vikings SGP odds: +650
Check out Ricky Dimon's full analysis for tonight's Bills vs Vikings Same Game Parlay
NFL Week 10 Picks
Keep an eye out for our expert NFL predictions for every Week 10 game as they are added throughout the week, as our experts look to build on their 11-3 run last week!
