NFL Week 10 Opening Lines, Odds & Best Bets: Lions look to continue winning streak in Munich

Week 10 of the 2026 NFL campaign is on the immediate horizon. It kicks off with Thursday Night Football between the Commanders and Giants, while the other primetime matchups are Steelers vs Bengals and Chargers vs Ravens. 

Make sure you check out our NFL predictions as we add our picks on the side and total for every game throughout the week – and throughout the entire season. Also don't miss the NFL best bets page for our top picks. For now, let's break down the NFL Week 10 opening lines and give our best early bet to make.  

NFL Week 10 opening lines and odds  

Odds available at DraftKings Sportsbook at time of publishing  

• Washington Commanders +1.5 (-110) vs New York Giants -1.5 (-110) - Thursday Night Football 
• New England Patriots +1.5 (-105) vs Detroit Lions -1.5 (-115) - Munich 
• Kansas City Chiefs -3 (-120) vs Atlanta Falcons +3 (+100) 
• Houston Texans -4.5 (-110) vs Cleveland Browns +4.5 (-110) 
• Minnesota Vikings +3 (-110) vs Green Bay Packers -3 (-110) 
• Jacksonville Jaguars -10 (-110) vs Tennessee Titans +10 (-110) 
• Miami Dolphins +2.5 (-110) vs Indianapolis Colts -2.5 (-110) 
• Carolina Panthers -1.5 (-110) vs New Orleans Saints +1.5 (-110) 
• Buffalo Bills -8.5 (-110) vs New York Jets +8.5 (-110) 
• Seattle Seahawks -3 (-110) vs Las Vegas Raiders +3 (-110) 
• Los Angeles Rams -7.5 (-110) vs Arizona Cardinals +7.5 (-10) 
• San Francisco 49ers -4.5 (-110) vs Dallas Cowboys +4.5 (-110) 
• Pittsburgh Steelers +3.5 (-102 vs Cincinnati Bengals -3.5 (-118) - Sunday Night Football  
• Los Angeles Chargers +3.5 (-120) vs Baltimore Ravens -3.5 (+100) - Monday Night Football 

Best bet for NFL Week 10: Detroit Lions -1.5 over New England Patriots (-115)  

It’s hard to have any faith in the Patriots after what they put on tape in Week 9. There were disastrous developments on both sides of the ball en route to a 45-27 home loss to Green Bay. New England watched Jordan Love complete 23 of 29 passes for 372 yards and three touchdowns. The Packers even rushed for 129 yards...and their ground game stinks! Offensively, Drake Maye threw three interceptions and really didn’t do anything well until second-half garbage time. It is a much different story for the Lions, who extended their winning streak to four games with a 19-9 victory at Miami. They have also defeated Green Bay and Minnesota during their current surge. 

Mike Vrabel might be able to out-coach Dan Campbell during a standard week, but a weird week of travel – with the two teams having to take their talents to Europe – probably takes that factor out of the equation. And right now Campbell has considerably superior personnel with which to work. The Lions should be able to take care of business in Munich, and giving less than a field goal feels like a steal. 

We'll have NFL picks for every game in Week 10!