Arizona Cardinals vs Cincinnati Bengals Predictions, Odds & Expert Picks for NFL Week 17 2025 for Sunday, 12/28/25

The Arizona Cardinals travel to Cincinnati, Ohio, for a Week 17 matchup against the Bengals, and like a few other games on Sunday’s slate, both teams are only fighting for draft position. These two squads had higher hopes entering the season, and while the Cardinals dropped another game last week against the Falcons, the Bengals got back in the win column with a 45-21 victory against the Dolphins. Although Arizona lost its seventh straight game, I think the Cards can put together a solid performance this week. First off, they’ve played fairly well against teams below .500 this season; they’re 2-3, but their 3 losses have come by 1 against the Titans, 3 against the Bucs and 7 against the Falcons. Now, they’ll go up against a Bengals team that is tied for last in the NFL in yards allowed per pass attempt (7.8) and 30th in the league in yards allowed per rush attempt (5.3).

On the flip side, this Bengals team hasn’t been able to gain any momentum this season, as they’re just 1-3 after a victory this season. They only won back-to-back games in Weeks 1 and 2, and even though they dominated the Dolphins last week on offense, their defense was shaky yet again. Rookie QB Quinn Ewers threw for 260 yards, and three different Dolphins running backs found the end zone. Additionally, Cincinnati was a perfect 6-6 in the red zone with Burrow throwing for 4 passing TDs, but that type of success for bad teams doesn’t usually continue. Teams that go 6-6 or better in the red zone the previous week are just 1-5 ATS in their next game when they’re a six-point favourite or more since 2007. 

Burrow is just 4-8 ATS in his career when he’s a 7-point favorite or higher, and he’s actually just 7-5 straight up in those games. While he’s been awesome as an underdog, he doesn’t typically live up to the hype as a big favorite. Therefore, I’ll back the Cardinals to keep this game within one touchdown.

Cardinals vs Bengals prediction: Cardinals +7 (-110) available at the time of publishing, playable at that number.

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