Arizona Cardinals vs Dallas Cowboys Prediction, Odds and MNF Picks for Monday, 11/03/25

Week 8 was another routine, poor performance from the Cowboys. Away from AT&T Stadium, Dallas realized their fourth loss of the season. For their fans, it wasn’t for the meek of heart. In most ways, the Broncos eviscerated the visitors, accruing 44 points and 426 yards on 7.5 yards per play. Through the air Bo Nix was electric, hitting 8.5 yards per pass and leading Denver to a pristine four touchdowns on five red-zone attempts. It was yet another indignation of the Cowboys’ defense, a group that was without Trevon Diggs, who’s now on injured reserve, and has been one of the worst units in the NFL all season (Dallas is 31st in opponent yards and points per play and opponent yards and points per game).

The good news is that Dallas is a different team at home, especially on offense. In three games at “Jerry’s’ world,” the Cowboys have averaged a ridiculous 41 points per game, and they did it against two NFC east foes (NYG, WAS) and the Packers, who qualify as a top-three defense according to Pro Football Focus.

The Cardinals rank 24th in the same category, which is our biggest issue with betting on Arizona. Of course, Kyler Murray will return in Week 9, which many see as an upgrade. We’re not so certain. Jacoby Brissett played well in two starts for Arizona, putting up respectable numbers (599 passing yards, four touchdowns, one interception) against two of the NFL’s best teams (IND, GB). Murray has been average at best this season, leading a mediocre passing attack that was averaging 5.97 yards per pass, a bottom-three ranking. 

No matter what way we look at it, the Cardinals have lost five games in a row for a reason. Their offense is often out-of-sync, and their defense rarely plays up to expectations for a full four quarters. Dallas has been a buzzsaw at home, and right now they have the far better quarterback.

Cardinals vs Cowboys best bet: Cowboys -2.5 (-115) available at time of publishing. Playable to 3.

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