Arizona Cardinals

Arizona Cardinals vs Dallas Cowboys Prediction, Odds and MNF Picks for Monday, 11/03/25

AT&T StadiumABC, ESPN
Cardinals
2-5
Cardinals
Mon Nov 3
Cowboys
3-4-1
Cowboys
Dallas Cowboys
Google News

Cardinals vs Cowboys Guest Expert Predictions

Point Spread Pick
DAL Cowboys -2.5(-115)

Week 8 was another routine, poor performance from the Cowboys. Away from AT&T Stadium, Dallas realized their fourth loss of the season. For their fans, it wasn’t for the meek of heart. In most ways, the Broncos eviscerated the visitors, accruing 44 points and 426 yards on 7.5 yards per play. Through the air Bo Nix was electric, hitting 8.5 yards per pass and leading Denver to a pristine four touchdowns on five red-zone attempts. It was yet another indignation of the Cowboys’ defense, a group that was without Trevon Diggs, who’s now on injured reserve, and has been one of the worst units in the NFL all season (Dallas is 31st in opponent yards and points per play and opponent yards and points per game).

The good news is that Dallas is a different team at home, especially on offense. In three games at “Jerry’s’ world,” the Cowboys have averaged a ridiculous 41 points per game, and they did it against two NFC east foes (NYG, WAS) and the Packers, who qualify as a top-three defense according to Pro Football Focus.

The Cardinals rank 24th in the same category, which is our biggest issue with betting on Arizona. Of course, Kyler Murray will return in Week 9, which many see as an upgrade. We’re not so certain. Jacoby Brissett played well in two starts for Arizona, putting up respectable numbers (599 passing yards, four touchdowns, one interception) against two of the NFL’s best teams (IND, GB). Murray has been average at best this season, leading a mediocre passing attack that was averaging 5.97 yards per pass, a bottom-three ranking. 

No matter what way we look at it, the Cardinals have lost five games in a row for a reason. Their offense is often out-of-sync, and their defense rarely plays up to expectations for a full four quarters. Dallas has been a buzzsaw at home, and right now they have the far better quarterback.

Cardinals vs Cowboys best bet: Cowboys -2.5 (-115) available at time of publishing. Playable to 3.

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Chris R. Farley
Game Totals PickBest Bet
Over 53.0(-120)

To allege that the Cardinals might be able to slow down or limit the Cowboys’ offense, we would need substantial evidence to support such a claim. Unfortunately for Arizona fans, that doesn’t exist. While the visiting team has some respectable marks, like their 6th-place ranking in opponent third down conversion rate (35.29%) and 7th-place ranking in opponent yards per pass (6.5), most data points suggest that they’re average at best. They are 13th in opponent points (22) and 19th in opponent yards per game (335.7), but even that data is somewhat positively skewed since they’ve faced poor offenses like New Orleans, Carolina, Tennessee, and a tremendously injured 49ers’ roster in Week 3 (and they still lost). Against superior offenses like Seattle, Indianapolis and Green Bay, the Cardinals permitted 27 points per game.

The Cowboys are statistically better than all of those NFL offenses but the Colts, and they’re far better than every program at home. Putting up 41 points per game at AT&T Stadium is one thing, averaging 441 yards at home is another. The addition of George Pickens has meant a significant uptick in production for Dak Prescott and their air-attack, a receiver that started to shine when CeeDee Lamb had to sit out in four contests this season. Now Pickens and Lamb are both healthy and apparently thick as thieves, two buddies who make it their goal to punish enemy defenses every week. Together they’ve accrued 1,091 yards and 7 touchdowns. On Monday they’ll battle a defense that’s 27th in opponent pass completion percentage (62.05%) and 25th in opponent pass yards per game (234.9). Without any weather interruptions, there is only one way to look.

Cardinals vs Cowboys prediction: Over 53 (-120) available at time of publishing. Playable to 54.5.

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Chris R. Farley
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Chris Farley

Chris is a writer for Pickswise who’s been handicapping the NFL since 2011. He began his public betting career as a betting writer, and has since become a contributing analyst for various betting sites and shows. He was a 5th place winner ($114k) in the 2021 NFL Circa Millions contest, and he owns his own sports betting podcast, Laying the Points. Chris approaches handicapping using psychosocial principles and nuanced market analysis. The NFL and NBA are his favorite and most profitable sports.
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