Arizona Cardinals

Arizona Cardinals vs Dallas Cowboys Prediction, Odds and MNF Picks for Today, 11/03/25

AT&T StadiumABC, ESPN
Cardinals
Cardinals
Today
Cowboys
Cowboys
LLLLL
Last 5
DWLWL
2-5Record3-4-1
4-3-0ATS Record4-4-0
4-3O/U Record6-2
Dallas Cowboys

Cardinals vs Cowboys Best Bets

Game Totals PickBest Bet
Over 53.0(-120)

To allege that the Cardinals might be able to slow down or limit the Cowboys’ offense, we would need substantial evidence to support such a claim. Unfortunately for Arizona fans, that doesn’t exist. While the visiting team has some respectable marks, like their 6th-place ranking in opponent third-down conversion rate (35.29%) and 7th-place ranking in opponent yards per pass (6.5), most data points suggest that they’re average at best. They are 13th in opponent points (22) and 19th in opponent yards per game (335.7), but even that data is somewhat positively skewed since they’ve faced poor offenses like New Orleans, Carolina, Tennessee, and a tremendously-injured 49ers’ roster in Week 3 (and they still lost). Against superior offenses like Seattle, Indianapolis and Green Bay, the Cardinals permitted 27 points per game.

The Cowboys are statistically better than all of those NFL offenses but the Colts, and they’re far better than every program at home. Putting up 41 points per game at AT&T Stadium is one thing, averaging 441 yards at home is another. The addition of George Pickens has meant a significant uptick in production for Dak Prescott and their air-attack, a receiver that started to shine when CeeDee Lamb had to sit out in 4 contests this season. Now Pickens and Lamb are both healthy and apparently thick as thieves, 2 buddies who make it their goal to punish enemy defenses every week. Together they’ve accrued 1,091 yards and 7 touchdowns. On Monday they’ll battle a defense that’s 27th in opponent pass completion percentage (62.05%) and 25th in opponent pass yards per game (234.9). Without any weather interruptions, there is only one way to look.

Cardinals vs Cowboys prediction: Over 53 (-120) available at time of publishing. Playable to 54.5.

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Chris R. Farley

Cardinals vs Cowboys Pickswise Expert Predictions

Point Spread Pick
DAL Cowboys -2.5(-115)

Week 8 was another routine, poor performance from the Cowboys. Away from AT&T Stadium, Dallas suffered their 4th loss of the season. For their fans, it wasn’t for the meek of heart. In most ways, the Broncos eviscerated the visitors, accruing 44 points and 426 yards on 7.5 yards per play. Through the air, Bo Nix was electric, hitting 8.5 yards per pass and leading Denver to a pristine 4 touchdowns on 5 red-zone attempts. It was yet another indignation of the Cowboys’ defense, a group that was without Trevon Diggs, who’s now on injured reserve, and has been one of the worst units in the NFL all season (31st in opponent yards, points per play, opponent yards and points per game). The good news is that Dallas is a different team at home, especially on offense. In 3 games at “Jerry’s’ world,” the Cowboys have averaged a ridiculous 41 points per game, and they did it against 2 NFC East foes (NYG, WAS) as well as the Packers, who qualify as a top-3 defense according to Pro Football Focus.

The Cardinals rank 24th in the same category, which is our biggest issue with betting on Arizona. Jacoby Brissett looks set to once again be under center, who has played well in 2 starts for Arizona, putting up respectable numbers (599 passing yards, 4 touchdowns, 1 interception) against 2 of the NFL’s best teams (IND, GB). However, no matter what way we look at it, the Cardinals have lost 5 games in a row for a reason. Their offense is often out of sync, and their defense rarely plays up to expectations for a full 4 quarters. Dallas has been a buzzsaw at home, and right now they have the far better quarterback.

Cardinals vs Cowboys best bet: Cowboys -2.5 (-115) available at time of publishing. Playable to 3.

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Chris R. Farley
Anytime Touchdown Scorer Pick
T. McBride (ARI) to score a TD(+105)

Nobody has benefited more from Jacoby Brissett filling in for Kyler Murray than Trey McBride. In the 2 games that Brissett has started, McBride has reeled in 18 of 24 targets, 146 yards and 3 touchdowns. As 3-point underdogs on the road to a woeful Cowboys defense, McBride should be a staple in the Cardinals’ offensive gameplan, most importantly in the red zone, where the Cowboys are allowing a touchdown on 69% of red-zone trips, which is in the bottom 5 in the NFL.

jutpicks
Justin Martin (JutPicks)
Anytime Touchdown Scorer Pick
M. Wilson (ARI) to score a TD(+250)

Like McBride, Michael Wilson has been a beneficiary of Brissett under center. With Murray at QB, Wilson was averaging fewer than 11 yards per game. Under Brissett, Wilson is up to 42 yards per game and playing over 75% of the snaps. We’re anticipating a negative game script for the Cardinals against a Cowboys offense that can light up the scoreboard — especially with question marks regarding Arizona’s running back room.

jutpicks
Justin Martin (JutPicks)
Chris is a writer for Pickswise who’s been handicapping the NFL since 2011. He began his public betting career as a betting writer, and has since become a contributing analyst for various betting sites and shows. He was a 5th place winner ($114k) in the 2021 NFL Circa Millions contest, and he owns his own sports betting podcast, Laying the Points. Chris approaches handicapping using psychosocial principles and nuanced market analysis. The NFL and NBA are his favorite and most profitable sports.
Read more about Chris Farley

Same Game Parlay

Alternate Point Spread
DAL Cowboys -5.5
Anytime Touchdown Scorer
J. Williams (DAL) to score a TD
Player Rushing Yards
B. Knight (ARI) - 50+ rush yds

Dallas Cowboys -5.5 alternate spread over Arizona Cardinals (+122)

This has not been the case in recent years, but the Cowboys are actually better at home than they are on the road this year. Yes, Jerry World has actually been kind to the home team in 2025. Dallas is undefeated (2-0-1) through 3 outings in its own building, while it is 1-4 when it has to travel. Dak Prescott and company are scoring an outrageous 41 points per game at home and should be in line for another huge performance against an Arizona outfit that is ranked #24 defensively overall by PFF.

On the other side of the ball, Jacoby Brissett is starting at quarterback for the Cardinals in place of an injured Kyler Murray. Their passing game was already bad to begin with (third worst in yards per pass attempt), so the visitors could struggle even against a generous Cowboys defense. There really isn’t anything to like about Arizona in this matchup. Give me the ‘Boys to win by a touchdown…and perhaps more.

Javonte Williams to score a touchdown (-160)

The Cardinals have given up almost as many rushing touchdowns (7) as passing (8). In fact, heading into Week 9, they have allowed the 3rd-fewest TDs through the air. As such, it would be no surprise if the Cowboys do their red-zone damage on the ground. That would be nothing new for Williams, who has been a scoring machine. The North Carolina product has already produced 9 touchdowns – 8 rushing, 1 receiving. He found the end zone twice last weekend against Denver, giving him 3 touchdowns in the past 2 contests. Williams has every reason to score at least once against Arizona on Monday Night Football.

Bam Knight to record 50+ rushing yards (-102)

With James Conner and Trey Benson on injured reserve, Knight has only Emari Demercado to compete with in the Cardinals’ backfield. Knight is RB1 on Monday and should be able to capitalize at the expense of a Cowboys defense that is giving up 146.0 rushing yards per game (29th in the NFL) on 4.9 yards per carry. The 3rd-year player out of NC State gained 57 carries on 14 attempts during last week’s loss to the Packers and he has scored a touchdown in 2 of the last 3 games.

Ricky Dimon

Pickswise Expert Prop Picks

Anytime Touchdown Scorer Pick
T. McBride (ARI) to score a TD(+105)

Nobody has benefited more from Jacoby Brissett filling in for Kyler Murray than Trey McBride. In the 2 games that Brissett has started, McBride has reeled in 18 of 24 targets, 146 yards and 3 touchdowns. As 3-point underdogs on the road to a woeful Cowboys defense, McBride should be a staple in the Cardinals’ offensive gameplan, most importantly in the red zone, where the Cowboys are allowing a touchdown on 69% of red-zone trips, which is in the bottom 5 in the NFL.

jutpicks
Justin Martin (JutPicks)
Anytime Touchdown Scorer Pick
M. Wilson (ARI) to score a TD(+250)

Like McBride, Michael Wilson has been a beneficiary of Brissett under center. With Murray at QB, Wilson was averaging fewer than 11 yards per game. Under Brissett, Wilson is up to 42 yards per game and playing over 75% of the snaps. We’re anticipating a negative game script for the Cardinals against a Cowboys offense that can light up the scoreboard — especially with question marks regarding Arizona’s running back room.

jutpicks
Justin Martin (JutPicks)

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Point Spread

The Cardinals are 8-2 against the spread in their last 10 games as road underdogs.

Game Totals

The Cowboys' last 3 home games have gone Over the total.

Money Line

The Cowboys have won their last 3 games when they have been favorites at home.

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