Arizona Cardinals vs Houston Texans Prediction, Odds and Picks for Sunday, 12/14/25

The Houston Texans will be trying to extend their winning streak to 6 games when they host the Arizona Cardinals in Week 15 of the NFL season on Sunday afternoon. Only the Patriots (10) have won more consecutive contests than the Texans. I expect that trend to continue, so my Cardinals vs Texans pick is for the home team to win and cover. Head coach DeMeco Ryans’ red-hot squad boasts an 8-5 record and has moved into AFC wild-card position — and in second place in the AFC South — ahead of Indianapolis. Houston’s defense is arguably the best in the entire league. The Texans are #1 in total defense, #1 in scoring defense, #4 against the pass and #5 against the run. Four straight opponents have stayed under 20 points, including the Bills, Colts and Chiefs.

Arizona, on the other hand, is a team in turmoil. It is 3-10 and has lost 5 games in a row. Quarterback Kyler Murray (foot) has not played since Week 5 and won’t play again this year — and probably not ever for this particular franchise. Jacoby Brissett has been solid in Murray’s absence, but this offense just isn’t dynamic. And when you are facing Houston, your offense better be electric if you want to have even a remote chance of success. On the other side of the ball, the Cardinals’ defense is 26th in scoring (26.8 ppg allowed) and their 24 sacks are among the worst in the NFL. The Cards are 1-4 against the spread in in their last 5 overall, while the Texans are 3-0 ATS in its last 3, 4-1 ATS in its last 5 on the road and 2-0 ATS in the last two head-to-head meetings. 

Arizona Cardinals vs Houston Texans prediction: Texans -9.5 (-110) available at time of publishing. Playable to -10.

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