HomeNFLNFL PredictionsArizona Cardinals vs Houston Texans Predictions, Odds & Expert Picks for NFL Week 15 2025

Arizona Cardinals vs Houston Texans Predictions, Odds & Expert Picks for NFL Week 15 2025 for Today, 12/14/25

Updated: 1:53 AM ET Dec 14, 2025

NRG StadiumFOX

Cardinals

1:00 PM ETToday

Texans

LLLLL	Last 5	WWWWW
3-10	Record	8-5
6-7-0	ATS Record	7-6-0
8-5	O/U Record	3-10

Cardinals vs Texans Best Bets

Game Totals PickBest Bet

Under 42.5(-108)

Reasoning

It’s hard to even describe just how good the Texans’ defense is. Perhaps the most telling way to say it is that the unit is so good that you might actually tune into a football game for the purpose of watching defense instead of offense. Yes, the Texans’ defense is legitimately fun to watch — and it is the main reason why my Cardinals vs. Texans pick is Under 42.5. They have recorded 36 sacks and have forced 22 turnovers (4th-most in the league). Moreover, the offense has committed the 3rd-fewest turnovers in the NFL (10) — so it rarely puts the defense in bad situations. Speaking of the offense, quarterback C.J. Stroud has been solid but unspectacular in 2 starts since missing 3 games with concussion. In those 2 appearances, he went a combined 37-of-66 for 479 yards, 1 TD and 1 INT.

Meanwhile, Brissett is playing well for the Cardinals but is not getting much help at all from the running game. And no matter what Brissett brings to the table on Sunday, it’s hard to like any offense’s chances against Houston at the moment. Will Anderson Jr., Danielle Hunter and others are probably going to wreak havoc in the backfield. I’m not even entirely positive that Arizona will avoid getting shut out. The under is 4-0 in the Texans’ last four overall and 2-0 in the last two head-to-head encounters.

Cardinals vs Texans prediction: Under 42.5 (-108) available at time of publishing. Playable to 40.5.

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Cardinals vs Texans Pickswise Expert Predictions

Point Spread Pick

HOU Texans -9.5(-110)

Reasoning

The Houston Texans will try to extend their winning streak to 6 games when they host the Arizona Cardinals in Week 15 of the NFL season on Sunday afternoon. Only the Patriots (10) have won more consecutive contests than the Texans. I expect that trend to continue, so my Cardinals vs. Texans pick is for the home team to win and cover.

Head coach DeMeco Ryans’ red-hot squad boasts an 8-5 record and has moved into AFC wild-card position — and in second place in the AFC South — ahead of Indianapolis. Houston’s defense is arguably the best in the entire league. The Texans are #1 in total defense, #1 in scoring defense, #4 against the pass and #5 against the run. Four straight opponents have stayed under 20 points, including the Bills, Colts and Chiefs.

Arizona, on the other hand, is a team in turmoil. It is 3-10 and has lost 5 games in a row. Quarterback Kyler Murray (foot) has not played since Week 5 and won’t play again this year — and probably not ever for this particular franchise. Jacoby Brissett has been solid in Murray’s absence, but this offense just isn’t dynamic. And when you face Houston, your offense better be electric if you want to have even a remote chance of success. On the other side of the ball, the Cardinals’ defense is 26th in scoring (26.8 ppg allowed) and their 24 sacks are among the worst in the NFL. The Cards are 1-4 against the spread in in their last 5 overall, while the Texans are 3-0 ATS in its last 3, 4-1 ATS in its last 5 on the road and 2-0 ATS in the last two head-to-head meetings.

Cardinals vs Texans prediction: Houston Texans -9.5 (-110) available at time of publishing. Playable to -10.

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Since graduating from Davidson (The College That Stephen Curry Built), I have been writing about sports -- just about any and all you can think of! -- and coaching tennis in Atlanta, GA. Beyond the four major sports, I am an avid tennis fan and cover the ATP Tour on a daily basis. If I'm not busy writing, you can generally find me on a tennis court or traveling the world wherever a sporting event takes me. For Ricky Dimon media enquiries, please email contact@pickswise.com.

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