Arizona Cardinals vs Seattle Seahawks Prediction, Odds and Picks for Sunday, 11/09/25

We have a fascinating clash in the NFC West on Sunday between the Arizona Cardinals and Seattle Seahawks. Seattle has been a team that I’ve been high on all season long, and that continued into last week, where the NFL world was put on notice after Sam Darnold and the Seattle offense absolutely bludgeoned the Commanders in prime time. The market has adjusted to how Seattle has played in recent weeks, and Mike Macdonald’s defense certainly looks like a unit that is capable of making a deep playoff run come January. However, even though I came into the season with a fairly bullish outlook on Seattle, I’m hesitant to back the Seahawks this week now that they’re being priced like the a top 5 team in the NFL. This number is a little expensive at a full touchdown, and there is reason to believe that the Cardinals can keep this one close.

Arizona has also been a team that I’ve consistently backed of late, and a lot of that was due to the insertion of Jacoby Brissett at the quarterback position. The Cardinals offense is simply better with Brissett at the controls, as Arizona is 11th in EPA per play and 9th in success rate since he took over for Kyler Murray in Week 6. Those numbers are even more impressive when you consider the injuries that Arizona has been fighting through over the last month. Furthermore, the Arizona defense has been quite solid — including an excellent performance against the Cowboys a week ago — and there is certainly a path for the Cardinals to hold down this Seattle passing offense, especially since we saw them limit the Seahawks to just 23 points back on September 25. I’ll take the points in what should be a close one in Seattle.

Cardinals vs Seahawks prediction: Cardinals +7 available at time of publishing. Playable to +6.5