Atlanta Falcons vs Arizona Cardinals Prediction, Odds and Picks for Sunday, 12/21/25

This is a quarterback matchup between Atlanta’s Kirk Cousins and Arizona’s Jacoby Brissett. Although both veterans clearly have at least a little bit left in the tank, neither one inspires a ton of confidence. You could maybe say that each one is solid, but they don’t provide any dynamic element to their respective offenses. That is part of the reason why my Falcons vs Cardinals pick is Under 48.5.

There is no denying that Arizona’s defense stinks, but can Atlanta take full advantage? Maybe not. WR1 Drake London is questionable with a knee injury and is trending toward missing a fourth consecutive contest. Tight end Kyle Pitts, who went crazy to the tune of 166 yards and 3 touchdowns last Thursday night, is questionable with a knee issue of his own. Fortunately for the Falcons, their defense has overachieved in 2025. The franchise’s previously nonexistent pass rush is second in the NFL in sacks, led by rookie first-round draft pick James Pearce Jr. This will not be an easy day at the office for Brissett, and the Cardinals don’t have the running game to capitalize on a vulnerable Atlanta run defense.

Atlanta Falcons vs Arizona Cardinals prediction: Under 48.5 (-110) available at time of publishing. Playable 48.

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