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Atlanta Falcons

Atlanta Falcons vs Arizona Cardinals Prediction, Odds and Picks for Today, 12/21/25

State Farm StadiumFOX
Falcons
Falcons
Today
Cardinals
Cardinals
LWLLW
Last 5
LLLLL
5-9Record3-11
6-7-1ATS Record6-8-0
7-7O/U Record9-5
Arizona Cardinals

Falcons vs Cardinals Pickswise Expert Predictions

Point Spread Pick
ATL Falcons -2.5(-120)

The Arizona Cardinals have lost 11 of their last 12 games heading into a home date with the Atlanta Falcons in Week 16 of the NFL season on Sunday afternoon. Arizona probably doesn’t have the talent or the motivation level to turn things around at this point in the season, so my Falcons vs. Cardinals pick is for the visitors to win and cover. Arizona’s defense is horrible. It has allowed 45 and 40 points the last 2 weeks and has given up 40 or more points a ridiculous 4 times during its current 6-game losing streak.

Much unlike the Cardinals, the Falcons are still putting forth a solid effort despite having long since been eliminated from playoff contention. Atlanta has won 2 games in a row, most recently upsetting the NFC South-leading Bucs in Week 15 after trailing by 2 touchdowns in the fourth quarter. That was on Thursday Night Football, so head coach Raheem Morris’ squad is effectively playing on a mini-bye week of rest. This is a great spot for a suddenly confident Falcons team against a Cardinals club that is among the worst in the entire NFL.

Falcons vs Cardinals prediction: Atlanta Falcons -2.5 (-120) available at time of publishing. Playable to -3.

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Ricky Dimon
Game Totals Pick
Under 48.5(-110)

This is a quarterback matchup between Atlanta’s Kirk Cousins and Arizona’s Jacoby Brissett. Although both veterans clearly have at least a little bit left in the tank, neither one inspires a ton of confidence. You could maybe say that each one is solid, but they don’t provide any dynamic element to their respective offenses. That is part of the reason why my Falcons vs. Cardinals pick is Under 48.5.

There is no denying that Arizona’s defense stinks, but can Atlanta take full advantage? Maybe not. WR1 Drake London is questionable with a knee injury and is trending toward missing a 4th consecutive contest. Tight end Kyle Pitts, who went crazy to the tune of 166 yards and 3 touchdowns last Thursday night, is questionable with a knee issue of his own. Fortunately for the Falcons, their defense has overachieved in 2025. The franchise’s previously nonexistent pass rush is 2nd in the NFL in sacks, led by rookie first-round draft pick James Pearce Jr. This will not be an easy day at the office for Brissett, and the Cardinals don’t have the running game to capitalize on a vulnerable Atlanta run defense.

Falcons vs Cardinals prediction: Under 48.5 (-110) available at time of publishing. Playable 48.

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Ricky Dimon
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Ricky Dimon

Since graduating from Davidson (The College That Stephen Curry Built), I have been writing about sports -- just about any and all you can think of! -- and coaching tennis in Atlanta, GA. Beyond the four major sports, I am an avid tennis fan and cover the ATP Tour on a daily basis. If I'm not busy writing, you can generally find me on a tennis court or traveling the world wherever a sporting event takes me. For Ricky Dimon media enquiries, please email contact@pickswise.com.
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Top Trends
Point Spread

The Cardinals are 1-4 against the spread in their last five games at home

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