Atlanta Falcons vs New Orleans Saints Prediction, Odds and Picks for Sunday, 11/23/25

It will be a showdown in the NFC South when the New Orleans Saints host the Atlanta Falcons on Sunday afternoon. It would have been hard to believe if before the season someone told you that the Saints — even at home — would be favored over the Falcons in Week 12. But that is, in fact, the case. It obviously has nothing to do with the Saints, who have been predictably bad. The Falcons, though, may be the most disappointing team in the entire league. Their 5-game losing streak has them at 3-7 overall and now both quarterback Michael Penix Jr. and wide receiver Drake London are sidelined. Penix will miss at least the next 4 games due to a knee injury; London is out 1 week at minimum with a knee issue of his own. Kirk Cousins under center and throwing to a group of pass-catches that doesn’t include London is a recipe for disaster.

The Saints own an even worse record than their division rivals, but they are a respectable 2-4 in their last 6 contests. Signs of improvement — however slim — are on display. They disposed of Carolina 17-7 in Week 11 — the same Carolina team that just swept the regular-season series against Atlanta. Now the Saints are coming off bye, which is a huge advantage heading into this matchup. New Orleans has won each of its last 3 home games against Atlanta. Expect that streak to continue this weekend.

Atlanta Falcons vs New Orleans Saints prediction: Saints -1.5 (-110) available at time of publishing. Playable at that number.

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